Adrenalectomy or superior cervical ganglionectomy modifies the nocturnal increase in rat pineal type II thyroxine 5'deiodinase

Juan Jimenez, Carmen Osuna, Russel J Reiter, Amalia Rubio, Juan M. Guerrero

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied the response of type II thyroxine 5'deiodinase (5'D) activity to superior cervical ganglionectomy (SCGX) or adrenalectomy (ADX) in the rat pineal gland and other tissues. The results show that no difference was found between controls and SCGX animals during the day, but at night, SCGX modified the day-night cycle of 5'D activity in the pineal gland. In the same way, ADX did not modify the enzyme activity during the day in pineal gland, harderian gland, hypophysis, or brain frontal cortex (BFC). However, in brown adipose tissue (BAT), where thyroid hormone metabolism is extremely dependent on α1-adren-ergic stimulation by blood circulating catecholamines, 5'D activity is significantly decreased. At the time point of maximal pineal 5'D activity in controls (02:00 h), ADX animals did not exhibit the nocturnal increase of the enzyme activity that occurs with control rats. Moreover, at 04:00 h ADX did not show any effect on pineal 5'D activity. These results seem to suggest that the presence of catecholamines in blood is necessary for the pineal 5'D activity nocturnal increase, although it does not participate in regulating the basal enzyme activity during the day. Key Words: Deiodinase - Thyroxine - Pineal gland - Adrenalectomy - Superior cervical ganglionectomy - Circadian rhythm.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalChronobiology International
Volume10
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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Ganglionectomy
iodide peroxidase
Iodide Peroxidase
pineal body
Pineal Gland
Adrenalectomy
thyroxine
rats
catecholamines
enzyme activity
Catecholamines
Enzymes
Harderian Gland
hormone metabolism
nocturnal activity
Brown Adipose Tissue
brown adipose tissue
pituitary gland
blood
Frontal Lobe

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Adrenalectomy or superior cervical ganglionectomy modifies the nocturnal increase in rat pineal type II thyroxine 5'deiodinase. / Jimenez, Juan; Osuna, Carmen; Reiter, Russel J; Rubio, Amalia; Guerrero, Juan M.

In: Chronobiology International, Vol. 10, No. 2, 1993, p. 87-93.

Research output: Contribution to journalArticle

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