Adrenalectomy but not gonadectomy affects rat pineal β-adrenergic receptor density

A. Gonzalez-Brito; R. J. Reiter; M. G. Tannenbaum; D. J. Jones

doi:10.1016/0304-3940(88)90612-X

Adrenalectomy but not gonadectomy affects rat pineal β-adrenergic receptor density

A. Gonzalez-Brito, R. J. Reiter, M. G. Tannenbaum, D. J. Jones

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Bilateral adrenalectomy, like chronic pineal denervation by means of superior cervical ganglionectomy, induced an increase in the morning levels of [¹²⁵I]iodopindolol (IPIN) binding to rat pineal membranes; this change may be related to the reduced input of catecholamines to the pinealocytes as suggested by the decrease in nocturnal pineal melatonin synthesis previously reported in adrenalectomized rats. Castrated rats did not show changes in IPIN binding to pineal membranes when measured either at middark or in chronically superior cervical ganglionectomized rats, suggesting that the regulation of pineal β-adrenergic receptors is independent from gonadal control.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Neuroscience Letters
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(88)90612-X
State	Published - Oct 17 1988

Keywords

Adrenal gland
Gonad
Male rat
Pineal gland
β-Adrenergic receptor

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(88)90612-X

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title = "Adrenalectomy but not gonadectomy affects rat pineal β-adrenergic receptor density",

abstract = "Bilateral adrenalectomy, like chronic pineal denervation by means of superior cervical ganglionectomy, induced an increase in the morning levels of [125I]iodopindolol (IPIN) binding to rat pineal membranes; this change may be related to the reduced input of catecholamines to the pinealocytes as suggested by the decrease in nocturnal pineal melatonin synthesis previously reported in adrenalectomized rats. Castrated rats did not show changes in IPIN binding to pineal membranes when measured either at middark or in chronically superior cervical ganglionectomized rats, suggesting that the regulation of pineal β-adrenergic receptors is independent from gonadal control.",

keywords = "Adrenal gland, Gonad, Male rat, Pineal gland, β-Adrenergic receptor",

author = "A. Gonzalez-Brito and Reiter, {R. J.} and Tannenbaum, {M. G.} and Jones, {D. J.}",

note = "Funding Information: This work was supported by NSF Grant DCB 8711241. A.G.B. is supported by a fellowship from a collaboration agreement between Cajacanarias and Autonomous Government of the Canary Islands (Spain).",

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T1 - Adrenalectomy but not gonadectomy affects rat pineal β-adrenergic receptor density

AU - Gonzalez-Brito, A.

AU - Reiter, R. J.

AU - Tannenbaum, M. G.

AU - Jones, D. J.

N1 - Funding Information: This work was supported by NSF Grant DCB 8711241. A.G.B. is supported by a fellowship from a collaboration agreement between Cajacanarias and Autonomous Government of the Canary Islands (Spain).

PY - 1988/10/17

Y1 - 1988/10/17

N2 - Bilateral adrenalectomy, like chronic pineal denervation by means of superior cervical ganglionectomy, induced an increase in the morning levels of [125I]iodopindolol (IPIN) binding to rat pineal membranes; this change may be related to the reduced input of catecholamines to the pinealocytes as suggested by the decrease in nocturnal pineal melatonin synthesis previously reported in adrenalectomized rats. Castrated rats did not show changes in IPIN binding to pineal membranes when measured either at middark or in chronically superior cervical ganglionectomized rats, suggesting that the regulation of pineal β-adrenergic receptors is independent from gonadal control.

AB - Bilateral adrenalectomy, like chronic pineal denervation by means of superior cervical ganglionectomy, induced an increase in the morning levels of [125I]iodopindolol (IPIN) binding to rat pineal membranes; this change may be related to the reduced input of catecholamines to the pinealocytes as suggested by the decrease in nocturnal pineal melatonin synthesis previously reported in adrenalectomized rats. Castrated rats did not show changes in IPIN binding to pineal membranes when measured either at middark or in chronically superior cervical ganglionectomized rats, suggesting that the regulation of pineal β-adrenergic receptors is independent from gonadal control.

KW - Adrenal gland

KW - Gonad

KW - Male rat

KW - Pineal gland

KW - β-Adrenergic receptor

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ER -

Adrenalectomy but not gonadectomy affects rat pineal β-adrenergic receptor density

Abstract

Keywords

ASJC Scopus subject areas

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