Adjuvant Therapy with 1% Alendronate Gel for Experimental Periodontitis Treatment in Rats

Natália De Campos Kajimoto, Yvonne De Paiva Buischi, Peter Michael Loomer, Timothy G. Bromage, Edilson Ervolino, Stephen Enrico Fucini, Natália Marcumini Pola, Beatriz Ommati Pirovani, Maria Juliana Sismeiro Morábito, Juliano Milanezi de Almeida, Flávia Aparecida Chaves Furlaneto, Maria José Hitomi Nagata

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.

Original languageEnglish (US)
Article numbere23
Pages (from-to)1-12
Number of pages12
JournalJournal of Periodontal and Implant Science
Volume51
DOIs
StatePublished - 2021

Keywords

  • Alendronate
  • Dental scaling
  • Periodontal disease
  • Periodontitis
  • Rats

ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics

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