Adjuvant radiation therapy for low stage testicular seminoma: Diagnosis and therapy in evolution

Tony Y. Eng, Richard S. Stack, Stephen M. Kimball

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We performed a retrospective study to evaluate the clinical outcome of patients with early stage testicular seminoma who received adjuvant radiation therapy after orchiectomy over the past 15 years. During the 15 year period, 61 patients were treated with adjuvant radiation therapy for stages I, IIA, and IIB testicular seminoma. Patients received from 2,000 to 4,000 cGy delivered by a Cobalt machine and later by a linear accelerator. Our standard treatment protocol was modified in 13 patients: 7 secondary to abnormal lymphangiography (LAG) parameters and 6 due to abnormal computed tomography findings. We analyzed each patient's outcome for survival, recurrence, and complications. We then compared outcomes, looking for differing trends based on evolving evaluation or treatment techniques. The average follow-up is 75 months, with an overall survival rate of 93%. The cause specific survival is 100%. Four patients died from intercurrent diseases; at time of autopsy, one of these patients was noted to have a small focus of seminoma in a lateral inguinal node. He died from widely disseminated Hodgkin's disease. Three patients, including the aforementioned one, had recurrent disease outside of the radiation field, yielding a recurrence rate of 5%. No significant long term treatment complications were reported, although 24% of patients had one or more complications from LAG. Regardless the various changes in patient evaluation and radiation treatment techniques over the past 15 years, adjuvant radiation therapy remains effective in patients with early stage testicular seminoma.

Original languageEnglish (US)
Pages (from-to)184-190
Number of pages7
JournalUrologic Oncology
Volume2
Issue number6
DOIs
StatePublished - 1996

Fingerprint

Seminoma
Radiotherapy
Therapeutics
Lymphography
Radiation
Recurrence
Particle Accelerators
Survival
Orchiectomy
Groin
Clinical Protocols
Cobalt
Hodgkin Disease
Autopsy
Survival Rate
Retrospective Studies
Tomography

Keywords

  • Lymphangiogram
  • Radiotherapy
  • Seminoma
  • Techniques

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Adjuvant radiation therapy for low stage testicular seminoma : Diagnosis and therapy in evolution. / Eng, Tony Y.; Stack, Richard S.; Kimball, Stephen M.

In: Urologic Oncology, Vol. 2, No. 6, 1996, p. 184-190.

Research output: Contribution to journalArticle

Eng, Tony Y. ; Stack, Richard S. ; Kimball, Stephen M. / Adjuvant radiation therapy for low stage testicular seminoma : Diagnosis and therapy in evolution. In: Urologic Oncology. 1996 ; Vol. 2, No. 6. pp. 184-190.
@article{ba2a610f75be461e9a0aa23d9da00fbf,
title = "Adjuvant radiation therapy for low stage testicular seminoma: Diagnosis and therapy in evolution",
abstract = "We performed a retrospective study to evaluate the clinical outcome of patients with early stage testicular seminoma who received adjuvant radiation therapy after orchiectomy over the past 15 years. During the 15 year period, 61 patients were treated with adjuvant radiation therapy for stages I, IIA, and IIB testicular seminoma. Patients received from 2,000 to 4,000 cGy delivered by a Cobalt machine and later by a linear accelerator. Our standard treatment protocol was modified in 13 patients: 7 secondary to abnormal lymphangiography (LAG) parameters and 6 due to abnormal computed tomography findings. We analyzed each patient's outcome for survival, recurrence, and complications. We then compared outcomes, looking for differing trends based on evolving evaluation or treatment techniques. The average follow-up is 75 months, with an overall survival rate of 93{\%}. The cause specific survival is 100{\%}. Four patients died from intercurrent diseases; at time of autopsy, one of these patients was noted to have a small focus of seminoma in a lateral inguinal node. He died from widely disseminated Hodgkin's disease. Three patients, including the aforementioned one, had recurrent disease outside of the radiation field, yielding a recurrence rate of 5{\%}. No significant long term treatment complications were reported, although 24{\%} of patients had one or more complications from LAG. Regardless the various changes in patient evaluation and radiation treatment techniques over the past 15 years, adjuvant radiation therapy remains effective in patients with early stage testicular seminoma.",
keywords = "Lymphangiogram, Radiotherapy, Seminoma, Techniques",
author = "Eng, {Tony Y.} and Stack, {Richard S.} and Kimball, {Stephen M.}",
year = "1996",
doi = "10.1016/S1078-1439(97)00011-2",
language = "English (US)",
volume = "2",
pages = "184--190",
journal = "Urologic Oncology: Seminars and Original Investigations",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Adjuvant radiation therapy for low stage testicular seminoma

T2 - Diagnosis and therapy in evolution

AU - Eng, Tony Y.

AU - Stack, Richard S.

AU - Kimball, Stephen M.

PY - 1996

Y1 - 1996

N2 - We performed a retrospective study to evaluate the clinical outcome of patients with early stage testicular seminoma who received adjuvant radiation therapy after orchiectomy over the past 15 years. During the 15 year period, 61 patients were treated with adjuvant radiation therapy for stages I, IIA, and IIB testicular seminoma. Patients received from 2,000 to 4,000 cGy delivered by a Cobalt machine and later by a linear accelerator. Our standard treatment protocol was modified in 13 patients: 7 secondary to abnormal lymphangiography (LAG) parameters and 6 due to abnormal computed tomography findings. We analyzed each patient's outcome for survival, recurrence, and complications. We then compared outcomes, looking for differing trends based on evolving evaluation or treatment techniques. The average follow-up is 75 months, with an overall survival rate of 93%. The cause specific survival is 100%. Four patients died from intercurrent diseases; at time of autopsy, one of these patients was noted to have a small focus of seminoma in a lateral inguinal node. He died from widely disseminated Hodgkin's disease. Three patients, including the aforementioned one, had recurrent disease outside of the radiation field, yielding a recurrence rate of 5%. No significant long term treatment complications were reported, although 24% of patients had one or more complications from LAG. Regardless the various changes in patient evaluation and radiation treatment techniques over the past 15 years, adjuvant radiation therapy remains effective in patients with early stage testicular seminoma.

AB - We performed a retrospective study to evaluate the clinical outcome of patients with early stage testicular seminoma who received adjuvant radiation therapy after orchiectomy over the past 15 years. During the 15 year period, 61 patients were treated with adjuvant radiation therapy for stages I, IIA, and IIB testicular seminoma. Patients received from 2,000 to 4,000 cGy delivered by a Cobalt machine and later by a linear accelerator. Our standard treatment protocol was modified in 13 patients: 7 secondary to abnormal lymphangiography (LAG) parameters and 6 due to abnormal computed tomography findings. We analyzed each patient's outcome for survival, recurrence, and complications. We then compared outcomes, looking for differing trends based on evolving evaluation or treatment techniques. The average follow-up is 75 months, with an overall survival rate of 93%. The cause specific survival is 100%. Four patients died from intercurrent diseases; at time of autopsy, one of these patients was noted to have a small focus of seminoma in a lateral inguinal node. He died from widely disseminated Hodgkin's disease. Three patients, including the aforementioned one, had recurrent disease outside of the radiation field, yielding a recurrence rate of 5%. No significant long term treatment complications were reported, although 24% of patients had one or more complications from LAG. Regardless the various changes in patient evaluation and radiation treatment techniques over the past 15 years, adjuvant radiation therapy remains effective in patients with early stage testicular seminoma.

KW - Lymphangiogram

KW - Radiotherapy

KW - Seminoma

KW - Techniques

UR - http://www.scopus.com/inward/record.url?scp=0030839104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030839104&partnerID=8YFLogxK

U2 - 10.1016/S1078-1439(97)00011-2

DO - 10.1016/S1078-1439(97)00011-2

M3 - Article

C2 - 21224167

AN - SCOPUS:0030839104

VL - 2

SP - 184

EP - 190

JO - Urologic Oncology: Seminars and Original Investigations

JF - Urologic Oncology: Seminars and Original Investigations

SN - 1078-1439

IS - 6

ER -