Adjuvant androgen deprivation for high-risk prostate cancer after radical prostatectomy: SWOG S9921 study

Tanya B. Dorff, Thomas W. Flaig, Catherine M. Tangen, Maha H.A. Hussain, Gregory P. Swanson, David P. Wood, Wael A. Sakr, Nancy A. Dawson, Naomi B. Haas, E. David Crawford, Nicholas J. Vogelzang, Ian M. Thompson, L. Michael Glode

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Purpose: Men with high-risk features (extraprostatic extension or high Gleason grade) face a high risk of prostate cancer recurrence after radical prostatectomy. Clinical trials of adjuvant systemic therapy for such patients have been limited. Patients and Methods: The SWOG (Southwest Oncology Group) S9921 study randomly assigned 983 men with high-risk features at prostatectomy to receive adjuvant therapy with androgen deprivation (ADT) alone or in combination with mitoxantrone chemotherapy. ADT consisted of goserelin and bicalutamide for 2 years. Results: Although the final primary treatment comparison results are not ready for publication, this article reports results in the ADT-alone control arm with a median follow-up of 4.4 years. For these 481 men, the estimated 5-year biochemical failure-free survival is 92.5% (95% CI, 90 to 95), and 5-year overall survival is 95.9% (95% CI, 93.9 to 97.9). Conclusion: The results of this trial, taken in context, make a compelling argument for counseling all high-risk patients with prostate cancer about adjuvant ADT. This article discusses the challenges in the design and implementation of clinical trials to take the next step forward in adjuvant therapy for prostate cancer because of the excellent survival achieved with currently available therapies and highlights the need for better molecular markers to personalize care.

Original languageEnglish (US)
Pages (from-to)2040-2045
Number of pages6
JournalJournal of Clinical Oncology
Volume29
Issue number15
DOIs
StatePublished - May 20 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Adjuvant androgen deprivation for high-risk prostate cancer after radical prostatectomy: SWOG S9921 study'. Together they form a unique fingerprint.

Cite this