Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

Hongdong Wang, Lei Shen, Xitai Sun, Fangcen Liu, Wenhuan Feng, Chunping Jiang, Xuehui Chu, Xiao Ye, Can Jiang, Yan Wang, Pengzi Zhang, Mengwei Zang, Dalong Zhu, Yan Bi

Research output: Contribution to journalArticle

Abstract

Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed tissues. Here we show that the number of adipose ILC1s increases in obese T2D patients and correlates with glycemic parameters and with the number of ILC1s in the blood; circulating ILC1 numbers decrease as a result of metabolic improvements after bariatric surgery. In vitro co-culture experiments show that human adipose ILC1s promote adipose fibrogenesis and CD11c+ macrophage activation. Reconstruction of the adipose ILC1 population in Prkdc−/−IL2rg−/− mice by adoptive transfer drives adipose fibrogenesis through activation of TGFβ1 signaling; however, transfer of Ifng−/− ILC1s has no effect on adipose fibrogenesis. Furthermore, inhibiting adipose accumulation of ILC1s using IL-12 neutralizing antibodies attenuates adipose tissue fibrosis and improves glycemic tolerance. Our data present insights into the mechanisms of local immune disturbances in obesity-related T2D.

Original languageEnglish (US)
Article number3254
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

obesity
adipose tissues
fibrosis
Medical problems
Type 2 Diabetes Mellitus
Adipose Tissue
Fibrosis
Obesity
activation
Lymphocytes
Tissue
effectors
macrophages
immunity
cells
Chemical activation
antibodies
surgery
blood
mice

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity. / Wang, Hongdong; Shen, Lei; Sun, Xitai; Liu, Fangcen; Feng, Wenhuan; Jiang, Chunping; Chu, Xuehui; Ye, Xiao; Jiang, Can; Wang, Yan; Zhang, Pengzi; Zang, Mengwei; Zhu, Dalong; Bi, Yan.

In: Nature communications, Vol. 10, No. 1, 3254, 01.12.2019.

Research output: Contribution to journalArticle

Wang, H, Shen, L, Sun, X, Liu, F, Feng, W, Jiang, C, Chu, X, Ye, X, Jiang, C, Wang, Y, Zhang, P, Zang, M, Zhu, D & Bi, Y 2019, 'Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity', Nature communications, vol. 10, no. 1, 3254. https://doi.org/10.1038/s41467-019-11270-1
Wang, Hongdong ; Shen, Lei ; Sun, Xitai ; Liu, Fangcen ; Feng, Wenhuan ; Jiang, Chunping ; Chu, Xuehui ; Ye, Xiao ; Jiang, Can ; Wang, Yan ; Zhang, Pengzi ; Zang, Mengwei ; Zhu, Dalong ; Bi, Yan. / Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity. In: Nature communications. 2019 ; Vol. 10, No. 1.
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AU - Chu, Xuehui

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