Adiponectin and Stnfr2 peripheral levels are associated with cardiovascular risk in patients with schizophrenia

Ingrid Caroline Silva Dias, Salvina Maria de Campos-Carli, Erica Leandro Marciano Vieira, Ana Paula Lucas Mota, Pâmela Santos Azevedo, Vivian Thaise da Silveira Anício, Fernanda Carneiro Guimarães, Lucas Machado Mantovani, Breno Fiúza Cruz, Antonio Lúcio Teixeira, João Vinícius Salgado

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: To investigate the association between cytokine peripheral levels and the risk of cardiovascular disease in patients with schizophrenia and controls. Methods: A sample of 40 patients and 40 control subjects participated in the study. Psychiatric diagnosis was established following structured clinical assessment. The Framingham Score was used to assess cardiovascular risk (CVR). Serum levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α were determined by cytometric bead array (CBA) technique, and the serum levels of IL-33, sST2, sTNFR1, sTNFR2, Leptin and Adiponectin by Enzyme-Linked Immunosorbent assay (ELISA). Results: Patients with schizophrenia showed greater frequency of moderate CVR when compared with controls (p = 0.14). In addition, patients showed higher levels of sTNFR2 and Adiponectin compared to controls (p = 0.007 and p < 0.001, respectively). Adiponectin and sTNFR2 were associated with CVR only in patients (p = 0.0002 and p = 0.033, respectively). In multivariate analysis controlling for socio-demographic and clinical confounders, illness duration (r = 0.492; p < 0.002) and sTNFR2 (r = 0.665; p < 0.004) were independent predictors of CVR. Conclusion: Our results reinforce the concept that patients with schizophrenia are at greater risk to develop cardiovascular diseases, and suggest that the associated chronic low-grade inflammation might play a role in this process.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalJournal of Psychiatric Research
StatePublished - May 2022
Externally publishedYes


  • Cardiovascular risk
  • Inflammation
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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