Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment

Mateus L. Levandowski, Thiago W. Viola, Saulo G. Tractenberg, Ant Ônio L. Teixeira, Elisa Brietzke, Moisés E. Bauer, Rodrigo Grassi-Oliveira

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Childhood maltreatment has been associated with addiction and immune dysregulation, although neurobiological substrates underlying this association remain largely unknown. The aim of the study was to compare plasma levels of adipokines during early abstinence in crack cocaine dependent women with (CM+) and without history of childhood maltreatment (CM-). One hundred four crack cocaine female users were followed for 20 days in a detoxification inpatient treatment unit. Plasma levels of adiponectin, resistin and leptin were assessed every 7 days during 3 weeks of follow-up. The Childhood Trauma Questionnaire (CTQ) retrospectively assessed childhood maltreatment history. A healthy control group was included to provide adipokines reference values (HC). All crack users increased leptin plasma levels during early abstinence despite concentrations remained lower in comparison with non-users group. Crack users reporting childhood maltreatment exhibited a significant reduction in plasma levels of adiponectin and resistin when compared to CM- group. In addition, only CM- participants increased plasma levels of adiponectin during detoxification. This is the first study evaluating adipokines during crack cocaine abstinence. Our results suggest a modulator effect of childhood maltreatment on inflammatory status in treatment-seeking crack cocaine dependents during early abstinence.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalPsychiatry Research
Volume210
Issue number2
DOIs
StatePublished - Dec 15 2013
Externally publishedYes

Keywords

  • Adiponectin
  • Child abuse
  • Follow-up study
  • Immune system
  • Inflammation
  • Leptin
  • Substance-related disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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