Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy

Xue Li; Masahiro Morita; Chisato Kikuguchi; Akinori Takahashi; Toru Suzuki; Tadashi Yamamoto

doi:10.1002/1873-3468.12550

Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy

Xue Li, Masahiro Morita, Chisato Kikuguchi, Akinori Takahashi, Toru Suzuki, Tadashi Yamamoto

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3^ad−/− mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3^ad−/− mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3^ad−/− WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Pparg^ldi/+ mice; thus, Cnot3^ad−/− mice exhibit lipodystrophy.

Original language	English (US)
Pages (from-to)	358-368
Number of pages	11
Journal	FEBS Letters
Volume	591
Issue number	2
DOIs	https://doi.org/10.1002/1873-3468.12550
State	Published - Jan 1 2017
Externally published	Yes

Keywords

Cnot3
cold intolerance
lipodystrophy

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1002/1873-3468.12550

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title = "Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy",

abstract = "Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3ad−/− mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3ad−/− mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3ad−/− WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Ppargldi/+ mice; thus, Cnot3ad−/− mice exhibit lipodystrophy.",

keywords = "Cnot3, cold intolerance, lipodystrophy",

author = "Xue Li and Masahiro Morita and Chisato Kikuguchi and Akinori Takahashi and Toru Suzuki and Tadashi Yamamoto",

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T1 - Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy

AU - Li, Xue

AU - Morita, Masahiro

AU - Kikuguchi, Chisato

AU - Takahashi, Akinori

AU - Suzuki, Toru

AU - Yamamoto, Tadashi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3ad−/− mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3ad−/− mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3ad−/− WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Ppargldi/+ mice; thus, Cnot3ad−/− mice exhibit lipodystrophy.

AB - Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3ad−/− mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3ad−/− mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3ad−/− WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Ppargldi/+ mice; thus, Cnot3ad−/− mice exhibit lipodystrophy.

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Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy

Abstract

Keywords

ASJC Scopus subject areas

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