Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb(+/-) mice

Daniel J. Riley, Alexander Yu Nikitin, Wen Hwa Lee

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The retinoblastoma gene (RB) is the prototypic tumor suppressor. Studies to date have demonstrated cancer suppression with tumor cells reconstituted with RB ex vivo and implanted into immunodeficient mice, as well as with germline transmission of a human RB transgene into tumor-prone Rb(+/-) mice. To mimic the therapy of cancer more closely, spontaneous pituitary melanotroph tumors arising in immunocompetent Rb(+/-) mice were treated with a recombinant adenovirus carrying RB cDNA. Intratumoral RB gene transfer decreased tumor cell proliferation, reestablished innervation by growth-regulatory dopaminergic neurons, inhibited the growth of tumors, and prolonged the life spans of treated animals.

Original languageEnglish (US)
Pages (from-to)1316-1321
Number of pages6
JournalNature Medicine
Volume2
Issue number12
DOIs
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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