Abstract
The endogenous neuromodulatory purine, adenosine, substantially attenuated neuronal degeneration when added to dissociated cortical cell cultures acutely deprived of either oxygen or glucose. The protective effect of adenosine was concentration-dependent between 30 and 1000 μM (EC50 about 100 μM), and could be mimicked by the stable adenosine analogue N6-cyclohexyladenosine (10 μM). Unlike postsynaptic glutamate receptor antagonists, which also block these forms of neuronal injury, adenosine did not alter the neurotoxicity of exogenously applied glutamate.
Original language | English (US) |
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Pages (from-to) | 323-327 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 89 |
Issue number | 3 |
DOIs | |
State | Published - Jul 8 1988 |
Externally published | Yes |
Keywords
- Adenosine
- Cell culture
- Cerebral cortex
- Cyclohexyladenosine
- Glutamate
- Hypoglycemia
- Hypoxia
ASJC Scopus subject areas
- General Neuroscience