Acyclic N-halamine-immobilized polyurethane: Preparation and antimicrobial and biofilm-controlling functions

Jie Luo, Nuala Porteous, Jiajin Lin, Yuyu Sun

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Hydroxyl groups were introduced onto polyurethane surfaces through 1,6-hexamethylene diisocyanate activation, followed by diethanolamine hydroxylation. Polymethacrylamide was covalently attached to the hydroxylated polyurethane through surface grafting polymerization of methacrylamide using cerium (IV) ammonium nitrate as an initiator. After bleach treatment, the amide groups of the covalently bound polymethacrylamide chains were transformed into N-halamines. The new N-halamine-immobilized polyurethane provided a total sacrifice of 107-108 colony forming units per milliliter of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), and Candida albicans (fungi) within 10 min and successfully prevented bacterial and fungal biofilm formation. The antimicrobial and biofilm-controlling effects were both durable and rechargeable, pointing to great potentials of the new acyclic N-halamine-immobilized polyurethane for a broad range of related applications.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalJournal of Bioactive and Compatible Polymers
Volume30
Issue number2
DOIs
StatePublished - Mar 27 2015

Keywords

  • N-halamine
  • Polyurethane
  • antimicrobial
  • biofilm
  • grafting
  • methacrylamide

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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