Acute yohimbine increases laboratory-measured impulsivity in normal subjects

Alan C. Swann, Daniel Birnbaum, Ashley A. Jagar, Donald M. Dougherty, F. Gerard Moeller

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Background: State-dependent changes in impulsivity may be related to norepinephrine. To examine possible relationships between norepinephrine and acute changes in impulsivity, we measured effects of yohimbine, which increases norepinephrine release by blocking alpha-2 noradrenergic receptors, on laboratory-measured impulsivity in healthy subjects without psychiatric or substance-use disorders. Methods: Impulsivity was assessed using the Immediate and Delayed Memory Tasks (IMT-DMT), derived from the Continuous Performance Test, before and after placebo or two doses of yohimbine, given 4 days apart. Blood pressure was monitored, and psychiatric symptoms were measured using self-rated visual analog scales. Results: Yohimbine was associated with a dose-related increase in impulsive IMT commission errors, with an increase of > 50% relative to baseline at the higher dose. The activation factor of the Internal State Scale was increased at the same dose. Conclusions: These results are consistent with increased impulsivity in normal subjects given yohimbine, possibly related to increased norepinephrine.

Original languageEnglish (US)
Pages (from-to)1209-1211
Number of pages3
JournalBiological Psychiatry
Issue number10
StatePublished - May 15 2005
Externally publishedYes


  • Continuous Performance Test
  • Human
  • Impulsivity
  • Norepinephrine
  • Yohimbine

ASJC Scopus subject areas

  • Biological Psychiatry


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