Acute tryptophan depletion: A method of studying antidepressant action

H. L. Miller; P. L. Delgado; R. M. Salomon; J. Licinio; L. C. Barr; D. S. Charney

Acute tryptophan depletion: A method of studying antidepressant action

H. L. Miller, P. L. Delgado, R. M. Salomon, J. Licinio, L. C. Barr, D. S. Charney

Joe R & Teresa Lozano School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Serotonin (5-HT) has been implicated in the pathophysiology of depressive syndromes and in the mechanism of antidepressant drug action. Rapid dietary depletion of tryptophan (TRP) provides a paradigm for studying the role of 5- HT in depressed patients. Drug-free depressed patients do not show mood changes during TRP depletion but about one third have a clinically apparent, transient improvement in mood on return to normal TRP intake. Depressed patients in clinical remission after 6 to 8 weeks of antidepressant therapy experience a transient depressive relapse during acute TRP depletion. The significance of these findings will be discussed. Tryptophan depletion in other psychiatric syndromes will also be reviewed.

Original language	English (US)
Pages (from-to)	28-35
Number of pages	8
Journal	Journal of Clinical Psychiatry
Volume	53
Issue number	10 SUPPL.
State	Published - Jan 1 1992

ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

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title = "Acute tryptophan depletion: A method of studying antidepressant action",

abstract = "Serotonin (5-HT) has been implicated in the pathophysiology of depressive syndromes and in the mechanism of antidepressant drug action. Rapid dietary depletion of tryptophan (TRP) provides a paradigm for studying the role of 5- HT in depressed patients. Drug-free depressed patients do not show mood changes during TRP depletion but about one third have a clinically apparent, transient improvement in mood on return to normal TRP intake. Depressed patients in clinical remission after 6 to 8 weeks of antidepressant therapy experience a transient depressive relapse during acute TRP depletion. The significance of these findings will be discussed. Tryptophan depletion in other psychiatric syndromes will also be reviewed.",

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AU - Miller, H. L.

AU - Delgado, P. L.

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AU - Licinio, J.

AU - Barr, L. C.

AU - Charney, D. S.

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N2 - Serotonin (5-HT) has been implicated in the pathophysiology of depressive syndromes and in the mechanism of antidepressant drug action. Rapid dietary depletion of tryptophan (TRP) provides a paradigm for studying the role of 5- HT in depressed patients. Drug-free depressed patients do not show mood changes during TRP depletion but about one third have a clinically apparent, transient improvement in mood on return to normal TRP intake. Depressed patients in clinical remission after 6 to 8 weeks of antidepressant therapy experience a transient depressive relapse during acute TRP depletion. The significance of these findings will be discussed. Tryptophan depletion in other psychiatric syndromes will also be reviewed.

AB - Serotonin (5-HT) has been implicated in the pathophysiology of depressive syndromes and in the mechanism of antidepressant drug action. Rapid dietary depletion of tryptophan (TRP) provides a paradigm for studying the role of 5- HT in depressed patients. Drug-free depressed patients do not show mood changes during TRP depletion but about one third have a clinically apparent, transient improvement in mood on return to normal TRP intake. Depressed patients in clinical remission after 6 to 8 weeks of antidepressant therapy experience a transient depressive relapse during acute TRP depletion. The significance of these findings will be discussed. Tryptophan depletion in other psychiatric syndromes will also be reviewed.

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Acute tryptophan depletion: A method of studying antidepressant action

Abstract

ASJC Scopus subject areas

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