Acute multilineage (B/myeloid) leukemia with RUNX1 duplication/amplification and hypereosinophilia

Allen Holmes; Jean Coviello; Gopalrao Velagaleti

doi:10.1111/ejh.12333

Acute multilineage (B/myeloid) leukemia with RUNX1 duplication/amplification and hypereosinophilia

Allen Holmes, Jean Coviello, Gopalrao Velagaleti

Department of Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 14-year-old girl presented with myalgias and decreased energy and was found to have a white count of 73 000 with 75% eosinophils. Flow cytometry and immunostains showed the blasts in the bone marrow expressed both myeloid and lymphoid markers. Patient was diagnosed with acute multilineage (B/Myeloid) leukemia. Genetic testing revealed four copies of the RUNX1 gene region in 25.5%, with a normal karyotype and no evidence of t(8;21) or t(12;21) by fluorescence in situ hybridization. RUNX1 translocations and amplifications have been implicated in acute myeloblastic leukemia, acute lymphoblastic leukemia, and MDS, but have not yet been seen with acute multilineage leukemia. Additionally, it is unclear what the risk stratification of this unique presentation will turn out to be.

Original language	English (US)
Pages (from-to)	449-452
Number of pages	4
Journal	European Journal of Haematology
Volume	93
Issue number	5
DOIs	https://doi.org/10.1111/ejh.12333
State	Published - Nov 1 2014

Keywords

AML
Cytogenetics
Hematopathology
Leukemia
RUNX1

ASJC Scopus subject areas

Hematology

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10.1111/ejh.12333

Cite this

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title = "Acute multilineage (B/myeloid) leukemia with RUNX1 duplication/amplification and hypereosinophilia",

abstract = "A 14-year-old girl presented with myalgias and decreased energy and was found to have a white count of 73 000 with 75% eosinophils. Flow cytometry and immunostains showed the blasts in the bone marrow expressed both myeloid and lymphoid markers. Patient was diagnosed with acute multilineage (B/Myeloid) leukemia. Genetic testing revealed four copies of the RUNX1 gene region in 25.5%, with a normal karyotype and no evidence of t(8;21) or t(12;21) by fluorescence in situ hybridization. RUNX1 translocations and amplifications have been implicated in acute myeloblastic leukemia, acute lymphoblastic leukemia, and MDS, but have not yet been seen with acute multilineage leukemia. Additionally, it is unclear what the risk stratification of this unique presentation will turn out to be.",

keywords = "AML, Cytogenetics, Hematopathology, Leukemia, RUNX1",

author = "Allen Holmes and Jean Coviello and Gopalrao Velagaleti",

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AB - A 14-year-old girl presented with myalgias and decreased energy and was found to have a white count of 73 000 with 75% eosinophils. Flow cytometry and immunostains showed the blasts in the bone marrow expressed both myeloid and lymphoid markers. Patient was diagnosed with acute multilineage (B/Myeloid) leukemia. Genetic testing revealed four copies of the RUNX1 gene region in 25.5%, with a normal karyotype and no evidence of t(8;21) or t(12;21) by fluorescence in situ hybridization. RUNX1 translocations and amplifications have been implicated in acute myeloblastic leukemia, acute lymphoblastic leukemia, and MDS, but have not yet been seen with acute multilineage leukemia. Additionally, it is unclear what the risk stratification of this unique presentation will turn out to be.

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Acute multilineage (B/myeloid) leukemia with RUNX1 duplication/amplification and hypereosinophilia

Abstract

Keywords

ASJC Scopus subject areas

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