Acute leukopenia associated with silver sulfadiazine therapy

Philip Valente; Judith L. Axelrod

doi:10.1097/00005373-197802000-00016

Acute leukopenia associated with silver sulfadiazine therapy

Philip Valente, Judith L. Axelrod

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene®). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.

Original language	English (US)
Pages (from-to)	146-147
Number of pages	2
Journal	Journal of Trauma - Injury, Infection and Critical Care
Volume	18
Issue number	2
DOIs	https://doi.org/10.1097/00005373-197802000-00016
State	Published - Feb 1978
Externally published	Yes

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Surgery

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10.1097/00005373-197802000-00016

Cite this

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title = "Acute leukopenia associated with silver sulfadiazine therapy",

abstract = "A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene{\textregistered}). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.",

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N2 - A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene®). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.

AB - A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene®). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.

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Acute leukopenia associated with silver sulfadiazine therapy

Abstract

ASJC Scopus subject areas

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