TY - JOUR
T1 - Acute kidney injury in pediatric heart failure
AU - Riley, Alyssa
AU - Gebhard, Daniel J.
AU - Akcan-Arikan, Ayse
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Acute kidney injury (AKI) is very common in pediatric medical and surgical cardiac patients. Not only is it an independent risk factor for increased morbidity and mortality in the short run, but repeated episodes of AKI lead to chronic kidney disease (CKD) especially in the most vulnerable hosts with multiple risk factors, such as heart transplant recipients. The cardiorenal syndrome, a term coined to emphasize the bidirectional nature of simultaneous or sequential cardiac-renal dysfunction both in acute and chronic settings, has been recently described in adults but scarcely reported in children. Despite the common occurrence and clinical and financial impact, AKI in pediatric heart failure outside of cardiac surgery populations remains poorly studied and there are no large-scale pediatric specific preventive or therapeutic studies to date. This article will review pediatric aspects of the cardiorenal syndrome in terms of pathophysiology, clinical impact and treatment options.
AB - Acute kidney injury (AKI) is very common in pediatric medical and surgical cardiac patients. Not only is it an independent risk factor for increased morbidity and mortality in the short run, but repeated episodes of AKI lead to chronic kidney disease (CKD) especially in the most vulnerable hosts with multiple risk factors, such as heart transplant recipients. The cardiorenal syndrome, a term coined to emphasize the bidirectional nature of simultaneous or sequential cardiac-renal dysfunction both in acute and chronic settings, has been recently described in adults but scarcely reported in children. Despite the common occurrence and clinical and financial impact, AKI in pediatric heart failure outside of cardiac surgery populations remains poorly studied and there are no large-scale pediatric specific preventive or therapeutic studies to date. This article will review pediatric aspects of the cardiorenal syndrome in terms of pathophysiology, clinical impact and treatment options.
KW - Acute kidney injury
KW - Cardiorenal syndrome
KW - Chronic kidney disease
KW - Congenital heart surgery
KW - Pediatric heart failure
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U2 - 10.2174/1573403X12666151119165628
DO - 10.2174/1573403X12666151119165628
M3 - Article
C2 - 26585035
AN - SCOPUS:84964240596
VL - 12
SP - 121
EP - 131
JO - Current Cardiology Reviews
JF - Current Cardiology Reviews
SN - 1573-403X
IS - 2
ER -