Acute kidney injury: A springboard for progression in chronic kidney disease

Manjeri A. Venkatachalam, Karen A. Griffin, Rongpei Lan, Hui Geng, Pothana Saikumar, Anil K. Bidani

Research output: Contribution to journalReview articlepeer-review

340 Scopus citations

Abstract

Recently published epidemiological and outcome analysis studies have brought to our attention the important role played by acute kidney injury (AKI) in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). AKI accelerates progression in patients with CKD; conversely, CKD predisposes patients to AKI. This research gives credence to older, well-thought-out wisdom that recovery from AKI is often not complete and is marked by residual structural damage. It also mirrors older experimental observations showing that unilateral nephrectomy, a surrogate for loss of nephrons by disease, compromises structural recovery and worsens tubulointerstitial fibrosis after ischemic AKI. Moreover, review of a substantial body of work on the relationships among reduced renal mass, hypertension, and pathology associated with these conditions suggests that impaired myogenic autoregulation of blood flow in the setting of hypertension, the arteriolosclerosis that results, and associated recurrent ischemic AKI in microscopic foci play important roles in the development of progressively increasing tubulointerstitial fibrosis. How nutrition, an additional factor that profoundly affects renal disease progression, influences these events needs reevaluation in light of information on the effects of calories vs. protein and animal vs. vegetable protein on injury and progression. Considerations based on published and emerging data suggest that a pathology that develops in regenerating tubules after AKI characterized by failure of differentiation and persistently high signaling activity is the proximate cause that drives downstream events in the interstitium: inflammation, capillary rarefaction, and fibroblast proliferation. In light of this information, we advance a comprehensive hypothesis regarding the pathophysiology of AKI as it relates to the progression of kidney disease. We discuss the implications of this pathophysiology for developing efficient therapeutic strategies to delay progression and avert ESRD.

Original languageEnglish (US)
Pages (from-to)F1078-F1094
JournalAmerican Journal of Physiology - Renal Physiology
Volume298
Issue number5
DOIs
StatePublished - May 2010

Keywords

  • End-stage renal disease
  • Kidney fibrosis
  • Signaling
  • Tubule atrophy
  • Tubule regeneration

ASJC Scopus subject areas

  • Physiology
  • Urology

Fingerprint Dive into the research topics of 'Acute kidney injury: A springboard for progression in chronic kidney disease'. Together they form a unique fingerprint.

Cite this