Acute Ischemic Stroke Presentation, Natural History, and Treatment

Sujani Bandela, Aaisha S. Mozumder, Lee A. Birnbaum

Research output: Chapter in Book/Report/Conference proceedingChapter


Acute ischemic stroke presents with various neurological manifestations that necessitate different emergent care pathways. Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) for acute ischemic stroke are being utilized more widely as a result of public awareness and expansion of clinical services with tele-stroke. Large vessel occlusion (LVO) stroke is being treated more expeditiously due to prehospital stroke severity assessments that enable EMS bypass protocols and Thrombectomy-Capable Centers that minimize EMS bypass travel times. Although MT has proven efficacy, IVT remains an important treatment for LVO, especially in drip-and-ship models. In addition to acute therapies, this chapter highlights common stroke syndrome presentations and outcomes, landmark clinical trials, neuroimaging modalities, and future directions.

Original languageEnglish (US)
Title of host publicationIntroduction to Vascular Neurosurgery
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783030881962
ISBN (Print)9783030881955
StatePublished - Jan 1 2022


  • Advanced neuroimaging
  • Door-in-door-out
  • Intravenous thrombolysis
  • Large vessel occlusion
  • Mechanical thrombectomy
  • Prehospital stroke severity assessments
  • Tenecteplase

ASJC Scopus subject areas

  • General Medicine


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