Acute fatty liver of pregnancy and long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency

William R. Treem, Piero Rinaldo, Daniel E. Hale, Charles A. Stanley, David S. Millington, Jeffrey S. Hyams, Sandra Jackson, Douglass M. Turnbull

Research output: Contribution to journalArticle

Abstract

The pathogenesis of acute fatty liver of pregnancy is unknown, but similarities in the clinical presentation and the histological appearance of the liver with those found in children with metabolic defects in the intra‐mitochondrial β‐oxidation pathway of the liver suggest that a disturbance in hepatic fatty acid oxidation may play a role. We report a woman with acute fatty liver of pregnancy who gave birth to a seemingly normal full‐term infant who was seen at 4 mo of age with hypoglycemia, coma and profound hepatic steatosis. The infant had a defect in fatty acid oxidation, long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency, and the mother proved to be heterozygous for this metabolic condition. We hypothesize that the interaction of an affected fetus with a female heterozygous for this defect in fatty acid oxidation in the late third trimester accounts for some cases of acute fatty liver of pregnancy. (Hepatology 1994;19:339–345).

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalHepatology
Volume19
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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Oxidoreductases
Fatty Acids
Liver
Hepatic Encephalopathy
Third Pregnancy Trimester
Gastroenterology
Hypoglycemia
Fetus
Mothers
Parturition
Acute fatty liver of pregnancy

ASJC Scopus subject areas

  • Hepatology

Cite this

Treem, W. R., Rinaldo, P., Hale, D. E., Stanley, C. A., Millington, D. S., Hyams, J. S., ... Turnbull, D. M. (1994). Acute fatty liver of pregnancy and long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency. Hepatology, 19(2), 339-345. https://doi.org/10.1002/hep.1840190211

Acute fatty liver of pregnancy and long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency. / Treem, William R.; Rinaldo, Piero; Hale, Daniel E.; Stanley, Charles A.; Millington, David S.; Hyams, Jeffrey S.; Jackson, Sandra; Turnbull, Douglass M.

In: Hepatology, Vol. 19, No. 2, 1994, p. 339-345.

Research output: Contribution to journalArticle

Treem, WR, Rinaldo, P, Hale, DE, Stanley, CA, Millington, DS, Hyams, JS, Jackson, S & Turnbull, DM 1994, 'Acute fatty liver of pregnancy and long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency', Hepatology, vol. 19, no. 2, pp. 339-345. https://doi.org/10.1002/hep.1840190211
Treem, William R. ; Rinaldo, Piero ; Hale, Daniel E. ; Stanley, Charles A. ; Millington, David S. ; Hyams, Jeffrey S. ; Jackson, Sandra ; Turnbull, Douglass M. / Acute fatty liver of pregnancy and long‐chain 3‐hydroxyacyl–coenzyme A dehydrogenase deficiency. In: Hepatology. 1994 ; Vol. 19, No. 2. pp. 339-345.
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