Acute Fatty Liver of Pregnancy

David B. Nelson; John J. Byrne; F. Gary Cunningham

doi:10.1007/978-3-030-70034-8_5

Acute Fatty Liver of Pregnancy

David B. Nelson
, John J. Byrne
, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal, condition that is characterized by hepatic failure typically in the third trimester associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, delivery, and supportive care have resulted in improved maternal morbidity and mortality. This chapter outlines the epidemiology, etiology, clinical presentation, diagnosis, management, and resolution of AFLP.

Original language	English (US)
Title of host publication	Obstetric Catastrophes
Subtitle of host publication	A Clinical Guide
Publisher	Springer International Publishing
Pages	45-59
Number of pages	15
ISBN (Electronic)	9783030700348
ISBN (Print)	9783030700331
DOIs	https://doi.org/10.1007/978-3-030-70034-8_5
State	Published - Jan 1 2021
Externally published	Yes

Keywords

Acute fatty liver of pregnancy
Acute kidney injury
Coagulopathy
Elevated liver enzymes
Encephalopathy
Hemolysis
Hepatic failure
Low platelets syndrome
Transaminitis

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-030-70034-8_5

Cite this

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abstract = "Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal, condition that is characterized by hepatic failure typically in the third trimester associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, delivery, and supportive care have resulted in improved maternal morbidity and mortality. This chapter outlines the epidemiology, etiology, clinical presentation, diagnosis, management, and resolution of AFLP.",

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AU - Byrne, John J.

AU - Cunningham, F. Gary

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Y1 - 2021/1/1

N2 - Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal, condition that is characterized by hepatic failure typically in the third trimester associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, delivery, and supportive care have resulted in improved maternal morbidity and mortality. This chapter outlines the epidemiology, etiology, clinical presentation, diagnosis, management, and resolution of AFLP.

AB - Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal, condition that is characterized by hepatic failure typically in the third trimester associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, delivery, and supportive care have resulted in improved maternal morbidity and mortality. This chapter outlines the epidemiology, etiology, clinical presentation, diagnosis, management, and resolution of AFLP.

KW - Acute fatty liver of pregnancy

KW - Acute kidney injury

KW - Coagulopathy

KW - Elevated liver enzymes

KW - Encephalopathy

KW - Hemolysis

KW - Hepatic failure

KW - Low platelets syndrome

KW - Transaminitis

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M3 - Chapter

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BT - Obstetric Catastrophes

PB - Springer International Publishing

ER -

Acute Fatty Liver of Pregnancy

Abstract

Keywords

ASJC Scopus subject areas

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