Acute effects of smoking marijuana on hormones, subjective effects and performance in male human subjects

Edward J. Cone, Rolley E. Johnson, James D. Moore, John D. Roache

Research output: Contribution to journalArticle

85 Scopus citations


Four healthy male subjects smoked two marijuana cigarettes or one marijuana and one placebo cigarette, or two placebo cigarettes on separate days in a random order crossover design. Each marijuana cigarette contained 2.8% delta-9-tetrahydrocannabinol (THC). Plasma hormones and THC were measured before and after each smoking session. Plasma LH was significantly depressed and cortisol was significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred. Concurrent measures of subjective effects via subscales of the Addiction Research Center Inventory, Single Dose Questionnaire and a Visual Analog Scale were generally elevated. Significant impairment on a psychomotor performance task paralleled elevations in subjective effects, hormone effects and peak THC determinations. Although all the hormone effects were within normal basal ranges, interactions between these systems, and their effects on behavior cannot be discounted.

Original languageEnglish (US)
Pages (from-to)1749-1754
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number6
StatePublished - Jun 1986
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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