Acute effects of dry extract of ginger on energy expenditure in eutrophic women: A randomized clinical trial

Gabriela Barbosa Pires Fagundes, Ana Maria dos Santos Rodrigues, Laís Bhering Martins, Nayara Mussi Monteze, Maria Isabel Toulson Davisson Correia, Antônio Lúcio Teixeira, Adaliene Versiani Matos Ferreira

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background & aims: The thermic effect of food (TEF) is one of the components of total energy expenditure (TEE). Some bioactive compounds present in food could be useful to increase TEE. In this context, ginger has been extensively used as a thermogenic food despite no clear effect has been demonstrated yet. Herein, we evaluated the acute thermogenic effect of gingerol, a bioactive compound present in ginger, in healthy women. Methods: We carried out a randomized double-masked, cross-over and placebo-controlled clinical trial with 20 healthy eutrophic women. Anthropometric, body composition, indirect calorimetry and clinical variables were collected at baseline and throughout the intervention phase. A standardized breakfast was offered together with two dry extract of ginger capsules (5% gingerol) or a placebo (cellulose). Indirect calorimetry, blood pressure, heart rate, axillary temperature and blood collection were assessed at baseline and thereafter, at 30, 60, 120, 180 and 240 min postprandial. The analyses were repeated with a minimum of seven days' washout period. Results: Ginger intake did not increase the TEF of a standardized breakfast compared to the placebo. Oxygen consumption, respiratory quotient, blood pressure, heart rate, axillary temperature and metabolic profile were not different as well. Conclusions: Our data show that gingerol did not modify the acute TEF in healthy women. More studies in human subjects, using different concentrations of gingerol, administration methods and intervention type (chronic effect) are necessary to clarify the putative thermogenic effect of ginger. Registered at (Thermogenic Effect of Ginger - NCT03089593).

Original languageEnglish (US)
Pages (from-to)168-174
Number of pages7
JournalClinical Nutrition ESPEN
StatePublished - Feb 2021
Externally publishedYes


  • Bioactive compounds
  • Energy expenditure
  • Ginger
  • Gingerol
  • Thermic effect of food

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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