Acute administration of leptin produces anxiolytic-like effects: A comparison with fluoxetine

Jing Liu, Jacob C. Garza, Jamaur Bronner, Chung Sub Kim, Wei Zhang, Xin-yun Lu

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Rationale: Our previous studies in rats have shown that the adipocyte-derived hormone leptin induces antidepressant-like effects with a behavioral profile similar to selective serotonin reuptake inhibitor (SSRI) antidepressants. Acute SSRI treatment causes paradoxical anxiogenic responses, although chronic treatment has therapeutic effects on anxiety. However, the role of leptin in anxiety remains to be established. Objectives: The scope of this study was to investigate the acute effects of leptin on anxiety-related behaviors in comparison with the SSRI antidepressant fluoxetine. Materials and methods: Adult male C57BL/6J mice received intraperitoneal injection of leptin or fluoxetine. Thirty minutes after injection, mice were subjected to the tail suspension test (TST) and forced swim test (FST) for evaluating antidepressant activity. Anxiety-like behavior was assessed in the elevated plus maze (EPM), social interaction, and open field tests 30 min following drug treatment. Results: While leptin and fluoxetine showed similar antidepressant-like behavioral effects in the TST and FST, they differed in the behavioral assays for anxiety. Open arm exploration in the EPM was increased by leptin but decreased by fluoxetine. Analysis of social interaction revealed that distinct social behavioral components were modulated by leptin and fluoxetine. The total time of active social behaviors was increased by leptin but reduced by fluoxetine. In addition, self-grooming, a non-social behavior, was suppressed by leptin treatment. Neither leptin nor fluoxetine produced significant effects in the open field test. Conclusions: In contrast to anxiogenic-like effects induced by acute fluoxetine, leptin elicits anxiolytic-like effects after acute administration. These results suggest that leptin has both antidepressant-like and anxiolytic-like properties.

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
Issue number4
StatePublished - Jan 2010


  • Anxiety
  • Depression
  • Elevated plus maze
  • Fluoxetine
  • Forced swim
  • Leptin
  • Social interaction
  • Tail suspension

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Acute administration of leptin produces anxiolytic-like effects: A comparison with fluoxetine'. Together they form a unique fingerprint.

Cite this