Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael G. Rinaldi, David Loebenberg, John R. Graybill

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

Original languageEnglish (US)
Pages (from-to)1436-1438
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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