Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Gloria M. González; Rolando Tijerina; Laura K. Najvar; Rosie Bocanegra; Michael G. Rinaldi; David Loebenberg; John R. Graybill

doi:10.1128/AAC.47.4.1436-1438.2003

Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael G. Rinaldi, David Loebenberg, John R. Graybill

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

Original language	English (US)
Pages (from-to)	1436-1438
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	47
Issue number	4
DOIs	https://doi.org/10.1128/AAC.47.4.1436-1438.2003
State	Published - Apr 1 2003
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.47.4.1436-1438.2003

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abstract = "Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.",

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AU - González, Gloria M.

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AU - Najvar, Laura K.

AU - Bocanegra, Rosie

AU - Rinaldi, Michael G.

AU - Loebenberg, David

AU - Graybill, John R.

PY - 2003/4/1

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AB - Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

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ER -

Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Abstract

ASJC Scopus subject areas

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