Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae

Marcos Restrepo; J. A. Velez; M. L. McElmeel; C. G. Whitney; J. H. Jorgensen

doi:10.1128/AAC.47.9.2974-2977.2003

Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae

Marcos Restrepo, J. A. Velez, M. L. McElmeel, C. G. Whitney, J. H. Jorgensen

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Daptomycin MICs at which 50% of isolates were inhibited (MIC ₅₀s) and MIC₉₀s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

Original language	English (US)
Pages (from-to)	2974-2977
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	47
Issue number	9
DOIs	https://doi.org/10.1128/AAC.47.9.2974-2977.2003
State	Published - Sep 1 2003

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.47.9.2974-2977.2003

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abstract = "Daptomycin MICs at which 50% of isolates were inhibited (MIC 50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.",

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AU - Velez, J. A.

AU - McElmeel, M. L.

AU - Whitney, C. G.

AU - Jorgensen, J. H.

PY - 2003/9/1

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N2 - Daptomycin MICs at which 50% of isolates were inhibited (MIC 50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

AB - Daptomycin MICs at which 50% of isolates were inhibited (MIC 50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

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Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae

Abstract

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