Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae

M. I. Restrepo, J. A. Velez, M. L. McElmeel, C. G. Whitney, J. H. Jorgensen

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5 Scopus citations


Daptomycin MICs at which 50% of isolates were inhibited (MIC 50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

Original languageEnglish (US)
Pages (from-to)2974-2977
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number9
Publication statusPublished - Sep 1 2003


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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