Activity of clarithromycin and its principal human metabolite against Haemophilus influenzae

J. H. Jorgensen; L. A. Maher; A. W. Howell

doi:10.1128/AAC.35.7.1524

Activity of clarithromycin and its principal human metabolite against Haemophilus influenzae

J. H. Jorgensen, L. A. Maher, A. W. Howell

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5 Scopus citations

Abstract

Clarithromycin is a new macrolide antibiotic which forms a microbiologically active principal in vivo metabolite, 14-OH-clarithromycin. The in vitro activities of clarithromycin and its metabolite were examined separately and in pharmacokinetically relevant fixed combinations of 4:1 and 2:1 against a group of 50 Haemophilus influenzae isolates. Broth microdilution susceptibility tests indicated that clarithromycin was less active than erythromycin against all but highly erythromycin-susceptible strains, while 14-OH-clarithromycin was generally more active than either antibiotic. An enhancement in activity against the majority of strains was demonstrated when clarithromycin and its metabolite were tested in combination.

Original language	English (US)
Pages (from-to)	1524-1526
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	35
Issue number	7
DOIs	https://doi.org/10.1128/AAC.35.7.1524
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.35.7.1524

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abstract = "Clarithromycin is a new macrolide antibiotic which forms a microbiologically active principal in vivo metabolite, 14-OH-clarithromycin. The in vitro activities of clarithromycin and its metabolite were examined separately and in pharmacokinetically relevant fixed combinations of 4:1 and 2:1 against a group of 50 Haemophilus influenzae isolates. Broth microdilution susceptibility tests indicated that clarithromycin was less active than erythromycin against all but highly erythromycin-susceptible strains, while 14-OH-clarithromycin was generally more active than either antibiotic. An enhancement in activity against the majority of strains was demonstrated when clarithromycin and its metabolite were tested in combination.",

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year = "1991",

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AU - Maher, L. A.

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AB - Clarithromycin is a new macrolide antibiotic which forms a microbiologically active principal in vivo metabolite, 14-OH-clarithromycin. The in vitro activities of clarithromycin and its metabolite were examined separately and in pharmacokinetically relevant fixed combinations of 4:1 and 2:1 against a group of 50 Haemophilus influenzae isolates. Broth microdilution susceptibility tests indicated that clarithromycin was less active than erythromycin against all but highly erythromycin-susceptible strains, while 14-OH-clarithromycin was generally more active than either antibiotic. An enhancement in activity against the majority of strains was demonstrated when clarithromycin and its metabolite were tested in combination.

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Activity of clarithromycin and its principal human metabolite against Haemophilus influenzae

Abstract

ASJC Scopus subject areas

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