Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Heather C. Yun; Michael W. Ellis; James H. Jorgensen

doi:10.1016/j.diagmicrobio.2007.06.023

Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Heather C. Yun, Michael W. Ellis, James H. Jorgensen

Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC₅₀ and MIC₉₀), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

Original language	English (US)
Pages (from-to)	463-466
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2007.06.023
State	Published - Dec 2007

Keywords

CA-MRSA
Ceftobiprole
MRSA
Military

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2007.06.023

Cite this

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title = "Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees",

abstract = "Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.",

keywords = "CA-MRSA, Ceftobiprole, MRSA, Military",

author = "Yun, {Heather C.} and Ellis, {Michael W.} and Jorgensen, {James H.}",

note = "Funding Information: This study was supported in part by a grant from Johnson and Johnson Research and Pharmaceutical Development (Raritan, NJ), who also provided the ceftobiprole powder for the study. The authors thank M. Leticia McElmeel and Letitia Fulcher for their excellent technical assistance. They thank Jan E. Patterson and Cynthia C. Kelly who contributed with the molecular analysis of the CA-MRSA isolates. ",

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doi = "10.1016/j.diagmicrobio.2007.06.023",

language = "English (US)",

volume = "59",

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journal = "Diagnostic Microbiology and Infectious Disease",

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AU - Yun, Heather C.

AU - Ellis, Michael W.

AU - Jorgensen, James H.

N1 - Funding Information: This study was supported in part by a grant from Johnson and Johnson Research and Pharmaceutical Development (Raritan, NJ), who also provided the ceftobiprole powder for the study. The authors thank M. Leticia McElmeel and Letitia Fulcher for their excellent technical assistance. They thank Jan E. Patterson and Cynthia C. Kelly who contributed with the molecular analysis of the CA-MRSA isolates.

PY - 2007/12

Y1 - 2007/12

N2 - Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

AB - Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

KW - CA-MRSA

KW - Ceftobiprole

KW - MRSA

KW - Military

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Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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