Activity of aztreonam and new beta-lactam antibiotics against penicillinase-producing Neisseria gonorrhoeae

D. A. Strandberg, J. H. Jorgensen, D. J. Drutz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The susceptibilities of a group of penicillinase-producing and none-penicillinase-producing isolates of Neisseria gonorrhoeae were determined to the monobactam aztreonam, four third-generation cephalosporins, and three second-generation cephalosporins. Aztreonam and the third-generation cephalosporins were highly active against both penicillin-resistant and penicillin-susceptible strains. MIC90s for penicillin-resistant isolates were the same as or not more than fourfold higher than for penicillin-susceptible strains. Ceftizoxime and defotaxime were the most active of the compounds tested; aztreonam, deftrazidime, moxalactam, and defuroxime were somewhate less active and had activities similar to another. Cefoxitin and cefamandole were the least active antibiotics tested.

Original languageEnglish (US)
Pages (from-to)955-959
Number of pages5
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume34
Issue number6
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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