Activity of a new carbapenem antibiotic, meropenem, against Haemophilus influenzae strains with β-lactamase- and non-enzyme-mediated resistance to ampicillin

J. H. Jorgensen, L. A. Maher, A. W. Howell

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Meropenem was 8- to 32-fold more active (MIC for 90% of strains = 0.125 μg/ml) than imipenem against a collection of Haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of β-lactamase or nonenzymatic mechanisms. MBCs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective MICs. Thus, meropenem demonstrated greater inhibitory activity than imipenem and activity comparable to that of cefotaxime against these selected strains.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number3
StatePublished - 1991

Fingerprint

meropenem
Ampicillin Resistance
Carbapenems
Imipenem
Haemophilus influenzae
Clavulanic Acid
Cefotaxime
Amoxicillin
Cephalosporins
Ampicillin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Activity of a new carbapenem antibiotic, meropenem, against Haemophilus influenzae strains with β-lactamase- and non-enzyme-mediated resistance to ampicillin. / Jorgensen, J. H.; Maher, L. A.; Howell, A. W.

In: Antimicrobial Agents and Chemotherapy, Vol. 35, No. 3, 1991, p. 600-602.

Research output: Contribution to journalArticle

@article{1c1938ba2f4f456fb0afe058fbf28286,
title = "Activity of a new carbapenem antibiotic, meropenem, against Haemophilus influenzae strains with β-lactamase- and non-enzyme-mediated resistance to ampicillin",
abstract = "Meropenem was 8- to 32-fold more active (MIC for 90{\%} of strains = 0.125 μg/ml) than imipenem against a collection of Haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of β-lactamase or nonenzymatic mechanisms. MBCs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective MICs. Thus, meropenem demonstrated greater inhibitory activity than imipenem and activity comparable to that of cefotaxime against these selected strains.",
author = "Jorgensen, {J. H.} and Maher, {L. A.} and Howell, {A. W.}",
year = "1991",
language = "English (US)",
volume = "35",
pages = "600--602",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - Activity of a new carbapenem antibiotic, meropenem, against Haemophilus influenzae strains with β-lactamase- and non-enzyme-mediated resistance to ampicillin

AU - Jorgensen, J. H.

AU - Maher, L. A.

AU - Howell, A. W.

PY - 1991

Y1 - 1991

N2 - Meropenem was 8- to 32-fold more active (MIC for 90% of strains = 0.125 μg/ml) than imipenem against a collection of Haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of β-lactamase or nonenzymatic mechanisms. MBCs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective MICs. Thus, meropenem demonstrated greater inhibitory activity than imipenem and activity comparable to that of cefotaxime against these selected strains.

AB - Meropenem was 8- to 32-fold more active (MIC for 90% of strains = 0.125 μg/ml) than imipenem against a collection of Haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of β-lactamase or nonenzymatic mechanisms. MBCs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective MICs. Thus, meropenem demonstrated greater inhibitory activity than imipenem and activity comparable to that of cefotaxime against these selected strains.

UR - http://www.scopus.com/inward/record.url?scp=0025967633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025967633&partnerID=8YFLogxK

M3 - Article

C2 - 2039214

AN - SCOPUS:0025967633

VL - 35

SP - 600

EP - 602

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 3

ER -