Activity of a new carbapenem antibiotic, meropenem, against Haemophilus influenzae strains with β-lactamase- and non-enzyme-mediated resistance to ampicillin

J. H. Jorgensen, L. A. Maher, A. W. Howell

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Meropenem was 8- to 32-fold more active (MIC for 90% of strains = 0.125 μg/ml) than imipenem against a collection of Haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of β-lactamase or nonenzymatic mechanisms. MBCs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective MICs. Thus, meropenem demonstrated greater inhibitory activity than imipenem and activity comparable to that of cefotaxime against these selected strains.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume35
Issue number3
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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