TY - JOUR
T1 - Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
AU - Aksenov, Alexander V.
AU - Smirnov, Alexander N.
AU - Magedov, Igor V.
AU - Reisenauer, Mary R.
AU - Aksenov, Nicolai A.
AU - Aksenova, Inna V.
AU - Pendleton, Alexander L.
AU - Nguyen, Gina
AU - Johnston, Robert K.
AU - Rubin, Michael
AU - De Carvalho, Annelise
AU - Kiss, Robert
AU - Mathieu, Véronique
AU - Lefranc, Florence
AU - Correa, Jaime
AU - Cavazos, David A.
AU - Brenner, Andrew J.
AU - Bryan, Brad A.
AU - Rogelj, Snezna
AU - Kornienko, Alexander
AU - Frolova, Liliya V.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/3/12
Y1 - 2015/3/12
N2 - Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
AB - Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
UR - https://www.scopus.com/pages/publications/84924666722
UR - https://www.scopus.com/pages/publications/84924666722#tab=citedBy
U2 - 10.1021/jm501518y
DO - 10.1021/jm501518y
M3 - Article
C2 - 25671501
AN - SCOPUS:84924666722
SN - 0022-2623
VL - 58
SP - 2206
EP - 2220
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 5
ER -