Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

Alexander V. Aksenov, Alexander N. Smirnov, Igor V. Magedov, Mary R. Reisenauer, Nicolai A. Aksenov, Inna V. Aksenova, Alexander L. Pendleton, Gina Nguyen, Robert K. Johnston, Michael Rubin, Annelise De Carvalho, Robert Kiss, Véronique Mathieu, Florence Lefranc, Jaime Correa, David A. Cavazos, Andrew Brenner, Brad A. Bryan, Snezna Rogelj, Alexander KornienkoLiliya V. Frolova

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.

Original languageEnglish (US)
Pages (from-to)2206-2220
Number of pages15
JournalJournal of Medicinal Chemistry
Volume58
Issue number5
DOIs
StatePublished - Mar 12 2015

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Pharmaceutical Preparations
Neoplasms
Apoptosis
Multiple Drug Resistance
Glioblastoma
Esophageal Neoplasms
Head and Neck Neoplasms
Glioma
Antineoplastic Agents
Melanoma
Cell Culture Techniques
Lung
Therapeutics
acetohydroxamic acid

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Aksenov, A. V., Smirnov, A. N., Magedov, I. V., Reisenauer, M. R., Aksenov, N. A., Aksenova, I. V., ... Frolova, L. V. (2015). Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. Journal of Medicinal Chemistry, 58(5), 2206-2220. https://doi.org/10.1021/jm501518y

Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. / Aksenov, Alexander V.; Smirnov, Alexander N.; Magedov, Igor V.; Reisenauer, Mary R.; Aksenov, Nicolai A.; Aksenova, Inna V.; Pendleton, Alexander L.; Nguyen, Gina; Johnston, Robert K.; Rubin, Michael; De Carvalho, Annelise; Kiss, Robert; Mathieu, Véronique; Lefranc, Florence; Correa, Jaime; Cavazos, David A.; Brenner, Andrew; Bryan, Brad A.; Rogelj, Snezna; Kornienko, Alexander; Frolova, Liliya V.

In: Journal of Medicinal Chemistry, Vol. 58, No. 5, 12.03.2015, p. 2206-2220.

Research output: Contribution to journalArticle

Aksenov, AV, Smirnov, AN, Magedov, IV, Reisenauer, MR, Aksenov, NA, Aksenova, IV, Pendleton, AL, Nguyen, G, Johnston, RK, Rubin, M, De Carvalho, A, Kiss, R, Mathieu, V, Lefranc, F, Correa, J, Cavazos, DA, Brenner, A, Bryan, BA, Rogelj, S, Kornienko, A & Frolova, LV 2015, 'Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells', Journal of Medicinal Chemistry, vol. 58, no. 5, pp. 2206-2220. https://doi.org/10.1021/jm501518y
Aksenov AV, Smirnov AN, Magedov IV, Reisenauer MR, Aksenov NA, Aksenova IV et al. Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. Journal of Medicinal Chemistry. 2015 Mar 12;58(5):2206-2220. https://doi.org/10.1021/jm501518y
Aksenov, Alexander V. ; Smirnov, Alexander N. ; Magedov, Igor V. ; Reisenauer, Mary R. ; Aksenov, Nicolai A. ; Aksenova, Inna V. ; Pendleton, Alexander L. ; Nguyen, Gina ; Johnston, Robert K. ; Rubin, Michael ; De Carvalho, Annelise ; Kiss, Robert ; Mathieu, Véronique ; Lefranc, Florence ; Correa, Jaime ; Cavazos, David A. ; Brenner, Andrew ; Bryan, Brad A. ; Rogelj, Snezna ; Kornienko, Alexander ; Frolova, Liliya V. / Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. In: Journal of Medicinal Chemistry. 2015 ; Vol. 58, No. 5. pp. 2206-2220.
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AU - Aksenov, Nicolai A.

AU - Aksenova, Inna V.

AU - Pendleton, Alexander L.

AU - Nguyen, Gina

AU - Johnston, Robert K.

AU - Rubin, Michael

AU - De Carvalho, Annelise

AU - Kiss, Robert

AU - Mathieu, Véronique

AU - Lefranc, Florence

AU - Correa, Jaime

AU - Cavazos, David A.

AU - Brenner, Andrew

AU - Bryan, Brad A.

AU - Rogelj, Snezna

AU - Kornienko, Alexander

AU - Frolova, Liliya V.

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