Activities of Cethromycin and Telithromycin against Recent North American Isolates of Streptococcus pneumoniae

James H. Jorgensen, Sharon A. Crawford, M. Leticia McElmeel, Cynthia G. Whitney

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The in vitro activities of two investigational ketolides, cethromycin (formerly ABT-773) and telithromycin, were determined for a selected group of 312 Streptococcus pneumoniae isolates from a national surveillance program. The MIC of cethromycin at which 50% of the isolates were inhibited was 0.008 μg/ml, and the MIC at which 90% of the isolates were inhibited was 0.06 μg/ml; the corresponding values for telithromycin were ≤0.015 and 0.25 μg/ml, respectively. For six quinupristin-dalfopristin-resistant strains, the cethromycin MICs were 0.25 to 16 μg/ml and the telithromycin MICs were 1 to 4 μg/ml. However, there was only 0.3% resistance to telithromycin.

Original languageEnglish (US)
Pages (from-to)605-607
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number2
DOIs
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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