Activation of the neutrophil respiratory burst oxidase

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

The neutrophil respiratory burst oxidase is a multicomponent activatable enzyme comprising one of the major phagocyte antimicrobial systems. In the genetic disorder chronic granulomatous disease, absent oxidase function is associated with recurrent, severe, and often life-threatening infections. The components of the oxidase system include both membrane-bound and soluble cytosolic proteins. A primary feature of stimulus-dependent activation is the translocation of a complex of cytosolic factors to the membrane, where they associate with a flavocytochrome enzyme. Interactions among the various oxidase components occur through a number of specific regions, including SH3 domains and proline-rich motifs. The fully assembled complex functions as an electron transport system, moving electrons from cytosolic NADPH to molecular oxygen to form superoxide, which, along with subsequent reactive products, exerts microbicidal and cytotoxic activities.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 2
StatePublished - 1999

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Neutrophil Activation
Oxidoreductases
Chronic Granulomatous Disease
Inborn Genetic Diseases
src Homology Domains
Membranes
Enzymes
Phagocytes
Electron Transport
NADP
Proline
Superoxides
Neutrophils
Electrons
Oxygen
Infection
superoxide-forming enzyme
Proteins

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Activation of the neutrophil respiratory burst oxidase. / Clark, Robert A.

In: Journal of Infectious Diseases, Vol. 179, No. SUPPL. 2, 1999.

Research output: Contribution to journalArticle

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