Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization

Golijeh Golarai, Jose E. Cavazos, Thomas P. Sutula

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Kindled seizures evoked by electrical stimulation of limbic pathways in the rat induce sprouting and synaptic reorganization of the mossy fiber pathway in the dentate gyrus (DG). To investigate whether seizures evoked by different methods also induce reorganization of this pathway, the distribution of mossy fiber terminals in the DG was examined with Timm histochemistry after systemic administration of pentylenetetrazol, a chemoconvulsant that reduces Cl- mediated GABAergic inhibition. Myoclonic seizures evoked by subconvulsant doses of pentylenetetrazol (24 mg/kg i.p.) were not accompanied by electrographic seizures in the DG, and did not induce mossy fiber sprouting. Generalized tonic-clonic seizures evoked by repeated administration of PTZ (24 mg/kg i.p.) were consistently accompanied by electrographic seizure activity in the DG, and induced sprouting and synaptic reorganization of the mossy fiber pathway. The results demonstrated that repeated generalized tonic-clonic seizures evoked by pentylenctetrazol induced mossy fiber synaptic reorganization when ictal electrographic discharges activated the circuitry of the DG.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalBrain Research
Volume593
Issue number2
DOIs
StatePublished - Oct 16 1992
Externally publishedYes

Keywords

  • Epilepsy
  • Hippocampus
  • Kindling
  • Plasticity
  • Sprouting
  • Timm histochemistry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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