Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

Richard O.C. Oreffo, Gregory R. Mundy, Saeid M. Seyedin, Lynda F. Bonewald

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


Although TGF beta is unquestionably an important growth regulatory polypeptide with effects on many cell types, the cellular mechanisms which release it from the binding proteins which mask its biological activity are not well understood. Here we show that when isolated osteoclasts are activated, they release active TGF beta from the latent TGF beta complex produced by bone organ cultures. Since active TGF beta has powerful inhibitory effects on osteoclast formation and bone resorption and stimulates osteoblast activity, is present in abundant amounts in the bone matrix and is released during hormone-stimulated osteoclastic bone resorption, the activation of TGF beta by stimulated osteoclasts may be an important regulatory step in normal bone remodeling.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Feb 15 1989

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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