Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates

Craig F. Ferris, Charles T. Snowdon, Jean A. King, John M. Sullivan, Toni E. Ziegler, David P. Olson, Nancy J. Schultz-Darken, Pamela L. Tannenbaum, Reinhold Ludwig, Ziji Wu, Almuth Einspanier, J. Thomas Vaughan, Timothy Q. Duong

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation. Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer. When fully conscious, monkeys were presented with the odors of a novel receptive female or an ovariectomized monkey. Both odors were presented during an imaging trial and the presentation of odors was counterbalanced. Significant changes in both positive and negative BOLD signal were mapped and averaged. Results: Periovulatory odors significantly increased positive BOLD signal in several cortical areas: the striatum, hippocampus, septum, periaqueductal gray, and cerebellum, in comparison with odors from ovariectomized monkeys. Conversely, negative BOLD signal was significantly increased in the temporal cortex, cingulate cortex, putamen, hippocampus, substantia nigra, medial preoptic area, and cerebellum with presentation of odors from ovariectomized marmosets as compared to periovulatory odors. A common neural circuit comprising the temporal and cingulate cortices, putamen, hippocampus, medial preoptic area, and cerebellum shared both the positive BOLD response to periovulatory odors and the negative BOLD response to odors of ovariectomized females. Conclusion: These data suggest the odor-driven enhancement and suppression of sexual arousal affect neuronal activity in many of the same general brain areas. These areas included not only those associated with sexual activity, but also areas involved in emotional processing and reward.

Original languageEnglish (US)
Pages (from-to)168-175
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume19
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Neural Pathways
Arousal
Primates
Haplorhini
Cerebellum
Callithrix
Hippocampus
Preoptic Area
Putamen
Gyrus Cinguli
Temporal Lobe
Sexual Behavior
Odorants
Periaqueductal Gray
Brain
Substantia Nigra
Reward
Motivation
Head

Keywords

  • Approach/avoidance
  • BOLD technique
  • Cerebellum
  • Common marmoset
  • Functional imaging
  • Magnetic resonance imaging
  • Neural circuit
  • Sexual motivation
  • Suppressed sexual activity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ferris, C. F., Snowdon, C. T., King, J. A., Sullivan, J. M., Ziegler, T. E., Olson, D. P., ... Duong, T. Q. (2004). Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates. Journal of Magnetic Resonance Imaging, 19(2), 168-175. https://doi.org/10.1002/jmri.10456

Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates. / Ferris, Craig F.; Snowdon, Charles T.; King, Jean A.; Sullivan, John M.; Ziegler, Toni E.; Olson, David P.; Schultz-Darken, Nancy J.; Tannenbaum, Pamela L.; Ludwig, Reinhold; Wu, Ziji; Einspanier, Almuth; Vaughan, J. Thomas; Duong, Timothy Q.

In: Journal of Magnetic Resonance Imaging, Vol. 19, No. 2, 02.2004, p. 168-175.

Research output: Contribution to journalArticle

Ferris, CF, Snowdon, CT, King, JA, Sullivan, JM, Ziegler, TE, Olson, DP, Schultz-Darken, NJ, Tannenbaum, PL, Ludwig, R, Wu, Z, Einspanier, A, Vaughan, JT & Duong, TQ 2004, 'Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates', Journal of Magnetic Resonance Imaging, vol. 19, no. 2, pp. 168-175. https://doi.org/10.1002/jmri.10456
Ferris, Craig F. ; Snowdon, Charles T. ; King, Jean A. ; Sullivan, John M. ; Ziegler, Toni E. ; Olson, David P. ; Schultz-Darken, Nancy J. ; Tannenbaum, Pamela L. ; Ludwig, Reinhold ; Wu, Ziji ; Einspanier, Almuth ; Vaughan, J. Thomas ; Duong, Timothy Q. / Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates. In: Journal of Magnetic Resonance Imaging. 2004 ; Vol. 19, No. 2. pp. 168-175.
@article{e97bb8c51e484e3cb3b7acda9d775f88,
title = "Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates",
abstract = "Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation. Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer. When fully conscious, monkeys were presented with the odors of a novel receptive female or an ovariectomized monkey. Both odors were presented during an imaging trial and the presentation of odors was counterbalanced. Significant changes in both positive and negative BOLD signal were mapped and averaged. Results: Periovulatory odors significantly increased positive BOLD signal in several cortical areas: the striatum, hippocampus, septum, periaqueductal gray, and cerebellum, in comparison with odors from ovariectomized monkeys. Conversely, negative BOLD signal was significantly increased in the temporal cortex, cingulate cortex, putamen, hippocampus, substantia nigra, medial preoptic area, and cerebellum with presentation of odors from ovariectomized marmosets as compared to periovulatory odors. A common neural circuit comprising the temporal and cingulate cortices, putamen, hippocampus, medial preoptic area, and cerebellum shared both the positive BOLD response to periovulatory odors and the negative BOLD response to odors of ovariectomized females. Conclusion: These data suggest the odor-driven enhancement and suppression of sexual arousal affect neuronal activity in many of the same general brain areas. These areas included not only those associated with sexual activity, but also areas involved in emotional processing and reward.",
keywords = "Approach/avoidance, BOLD technique, Cerebellum, Common marmoset, Functional imaging, Magnetic resonance imaging, Neural circuit, Sexual motivation, Suppressed sexual activity",
author = "Ferris, {Craig F.} and Snowdon, {Charles T.} and King, {Jean A.} and Sullivan, {John M.} and Ziegler, {Toni E.} and Olson, {David P.} and Schultz-Darken, {Nancy J.} and Tannenbaum, {Pamela L.} and Reinhold Ludwig and Ziji Wu and Almuth Einspanier and Vaughan, {J. Thomas} and Duong, {Timothy Q.}",
year = "2004",
month = "2",
doi = "10.1002/jmri.10456",
language = "English (US)",
volume = "19",
pages = "168--175",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates

AU - Ferris, Craig F.

AU - Snowdon, Charles T.

AU - King, Jean A.

AU - Sullivan, John M.

AU - Ziegler, Toni E.

AU - Olson, David P.

AU - Schultz-Darken, Nancy J.

AU - Tannenbaum, Pamela L.

AU - Ludwig, Reinhold

AU - Wu, Ziji

AU - Einspanier, Almuth

AU - Vaughan, J. Thomas

AU - Duong, Timothy Q.

PY - 2004/2

Y1 - 2004/2

N2 - Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation. Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer. When fully conscious, monkeys were presented with the odors of a novel receptive female or an ovariectomized monkey. Both odors were presented during an imaging trial and the presentation of odors was counterbalanced. Significant changes in both positive and negative BOLD signal were mapped and averaged. Results: Periovulatory odors significantly increased positive BOLD signal in several cortical areas: the striatum, hippocampus, septum, periaqueductal gray, and cerebellum, in comparison with odors from ovariectomized monkeys. Conversely, negative BOLD signal was significantly increased in the temporal cortex, cingulate cortex, putamen, hippocampus, substantia nigra, medial preoptic area, and cerebellum with presentation of odors from ovariectomized marmosets as compared to periovulatory odors. A common neural circuit comprising the temporal and cingulate cortices, putamen, hippocampus, medial preoptic area, and cerebellum shared both the positive BOLD response to periovulatory odors and the negative BOLD response to odors of ovariectomized females. Conclusion: These data suggest the odor-driven enhancement and suppression of sexual arousal affect neuronal activity in many of the same general brain areas. These areas included not only those associated with sexual activity, but also areas involved in emotional processing and reward.

AB - Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation. Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer. When fully conscious, monkeys were presented with the odors of a novel receptive female or an ovariectomized monkey. Both odors were presented during an imaging trial and the presentation of odors was counterbalanced. Significant changes in both positive and negative BOLD signal were mapped and averaged. Results: Periovulatory odors significantly increased positive BOLD signal in several cortical areas: the striatum, hippocampus, septum, periaqueductal gray, and cerebellum, in comparison with odors from ovariectomized monkeys. Conversely, negative BOLD signal was significantly increased in the temporal cortex, cingulate cortex, putamen, hippocampus, substantia nigra, medial preoptic area, and cerebellum with presentation of odors from ovariectomized marmosets as compared to periovulatory odors. A common neural circuit comprising the temporal and cingulate cortices, putamen, hippocampus, medial preoptic area, and cerebellum shared both the positive BOLD response to periovulatory odors and the negative BOLD response to odors of ovariectomized females. Conclusion: These data suggest the odor-driven enhancement and suppression of sexual arousal affect neuronal activity in many of the same general brain areas. These areas included not only those associated with sexual activity, but also areas involved in emotional processing and reward.

KW - Approach/avoidance

KW - BOLD technique

KW - Cerebellum

KW - Common marmoset

KW - Functional imaging

KW - Magnetic resonance imaging

KW - Neural circuit

KW - Sexual motivation

KW - Suppressed sexual activity

UR - http://www.scopus.com/inward/record.url?scp=10744229978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744229978&partnerID=8YFLogxK

U2 - 10.1002/jmri.10456

DO - 10.1002/jmri.10456

M3 - Article

C2 - 14745749

AN - SCOPUS:10744229978

VL - 19

SP - 168

EP - 175

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -