Activation of intestinal mitochondrial phospholipase D by polyamines and monoamines

Muniswamy Madesh, Kunissery A. Balasubramanian

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. Stimulation of PA formation by spermine was enhanced by the presence of calcium. Since polyamines are known to alter the calcium transport by mitochondria and PA is known to possess an ionophore effect, stimulation of PA formation in mitochondria by polyamines suggests that polyamine-induced alteration in calcium homeostasis might involve a PA related mechanism.

Original languageEnglish (US)
Pages (from-to)324-330
Number of pages7
JournalBiochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume1348
Issue number3
DOIs
StatePublished - Oct 18 1997
Externally publishedYes

Keywords

  • Intestinal mitochondria
  • Monoamines
  • Phosphatidic acid
  • Phospholipase D
  • Polyamines

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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