Activation of innate immune antiviral responses by Nod2

Ahmed Sabbah, Te Hung Chang, Rosalinda Harnack, Victoria Frohlich, Kaoru Tominaga, Peter H. Dube, Yan Xiang, Santanu Bose

Research output: Contribution to journalArticlepeer-review

460 Scopus citations

Abstract

Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-β (IFN-β). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms.

Original languageEnglish (US)
Pages (from-to)1073-1080
Number of pages8
JournalNature Immunology
Volume10
Issue number10
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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