@article{f18ce3dfd4e44ef79822d1146e46df93,
title = "Activation of innate immune antiviral responses by Nod2",
abstract = "Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-β (IFN-β). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms.",
author = "Ahmed Sabbah and Chang, {Te Hung} and Rosalinda Harnack and Victoria Frohlich and Kaoru Tominaga and Dube, {Peter H.} and Yan Xiang and Santanu Bose",
note = "Funding Information: We thank K. Li (University of Tennessee Health Science Center) for reagents; A. Garcia-Sastre (Mount Sinai School of Medicine) for influenza A virus; Z.J. Chen (University of Texas Southwestern Medical Center) for MAVS-deficient MEFs; the Core Optical Imaging Facility (University of Texas Health Science Center at San Antonio) for confocal images; and K. Moncada Gorena and C. Thomas in the Flow Cytometry Core Facility (supported by the National Institutes of Health (P30 CA54174 to the San Antonio Cancer Institute; P30 AG013319 to the Nathan Shock Center; and P01AG19316)) for flow cytometry. Supported by National Institutes of Health (AI069062 to S.B., CA129246 to S.B. and T32-DE14318 to A.S. and AI067716 to P.H.D.) and the American Lung Association (RG-49629-N to S.B. and AI067716 to P.H.D.).",
year = "2009",
doi = "10.1038/ni.1782",
language = "English (US)",
volume = "10",
pages = "1073--1080",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Research",
number = "10",
}