Activation of cerebrocortical type II 5′-deiodinase activity in Syrian hamsters kept under short photoperiod and reduced ambient temperature

Manuel Puig-Domingo, Juan Miguel Guerrero, Mary K. Vaughan, John C. Little, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cerebrocortical type II thyroxine 5′-deiodinase (5′-D II) was studied in the Syrian hamster. Animals maintained in 14 hr light/day and 20°C ambient temperature and then subjected to acute cold exposure (4°C) for 4 hours did not exhibit changes in cortical 5′-D II activity. Prolonged exposure of hamsters to natural autumnal short photoperiods and reduced ambient temperatures for 8 weeks increased cortical 5′-D II activity compared to hamsters maintained inside under controlled long photoperiod (14:10 LD) and temperature (20 ± 2°C) conditions. Animals given subcutaneous implants of melatonin and exposed to the natural autumnal condition for 8 weeks exhibited a greater increase in the cortical 5′-D II activity than that in hamsters with blank pellets kept under the same conditions of reduced photoperiod and temperature. Type II 5′-deiodinase activity was not affected by treatment with 6-methoxy-2-benzoxazolinone (6-MBOA), a compound with a chemical structure related to melatonin. All animals maintained outdoors in the natural photoperiod and temperature conditions had depressed circulating thyroxine (T4) and elevated triiodothyronine (T3) concentrations; neither implants of melatonin nor 6-MBOA affected these thyroid hormone levels. It is concluded that serum T4 is depressed and cerebrocortical 5′-D II activity is stimulated despite the elevation of T3 levels in this autumnal condition. These responses, unlike classic pineal-mediated responses to environmental changes, are not blocked by subcutaneous implants of melatonin. However, chronic administration of melatonin might augment the cortical 5′-D II response to low serum T4 or some other component of the autumnal condition.

Original languageEnglish (US)
Pages (from-to)975-979
Number of pages5
JournalBrain Research Bulletin
Volume22
Issue number6
DOIs
StatePublished - Jun 1989

Keywords

  • Cerebral cortex Cold Melatonin Type II thyroxine 5′-deiodinase T T 6-Methoxy-2-benzoxazolinone Hamster

ASJC Scopus subject areas

  • Neuroscience(all)

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