Activation of BPV-1 replication in vitro by the transcription factor E2

Liu Yang, Rong Li, Ian J. Mohr, Robin Clark, Michael R. Botchan

Research output: Contribution to journalArticlepeer-review

240 Scopus citations


Soluble extracts from uninfected murine cells supplemented with purified viral E1 and E2 proteins support the replication of exogenously added papilloma virus DNA. The E2 transactivator stimulates the binding of the E1 replication protein to the minimal origin of replication and activates DNA replication. These results support the concept that transcription factors have a direct role in the initiation of DNA replication in eukaryotes by participating in the assembly of a complex at the origin of replication.

Original languageEnglish (US)
Pages (from-to)628-632
Number of pages5
Issue number6345
StatePublished - 1991

ASJC Scopus subject areas

  • General


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