Activation of B cells by a dendritic cell-targeted oral vaccine

Bikash Sahay, Jennifer L. Owen, Tao Yang, Mojgan Zadeh, Yaíma L. Lightfoot, Jun Wei Ge, Mansour Mohamadzadeh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Production of long-lived, high affinity humoral immunity is an essential characteristic of successful vaccination and requires cognate interactions between T and B cells in germinal centers. Within germinal centers, specialized T follicular helper cells assist B cells and regulate the antibody response by mediating the differentiation of B cells into memory or plasma cells after exposure to T cell-dependent antigens. It is now appreciated that local immune responses are also essential for protection against infectious diseases that gain entry to the host by the mucosal route; therefore, targeting the mucosal compartments is the optimum strategy to induce protective immunity. However, because the gastrointestinal mucosae are exposed to large amounts of environmental and dietary antigens on a daily basis, immune regulatory mechanisms exist to favor tolerance and discourage autoimmunity at these sites. Thus, mucosal vaccination strategies must ensure that the immunogen is efficiently taken up by the antigen presenting cells, and that the vaccine is capable of activating humoral and cellular immunity, while avoiding the induction of tolerance. Despite significant progress in mucosal vaccination, this potent platform for immunotherapy and disease prevention must be further explored and refined. Here we discuss recent progress in the understanding of the role of different phenotypes of B cells in the development of an efficacious mucosal vaccine against infectious disease.

Original languageEnglish (US)
Pages (from-to)867-877
Number of pages11
JournalCurrent Pharmaceutical Biotechnology
Volume14
Issue number10
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • B-1 cells
  • Bacillus anthracis
  • Germinal centers
  • Humoral immune response
  • Lactobacillus
  • Mucosal vaccine
  • Oral vaccine

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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