Abstract
Using the patch-clamp method, we found that methylene blue (MB), a free radical inhibitor of guanylyl cyclase, activated large, Ca2+-activated K+ channels (BK(Ca)) in either cell attached or excised, inside-out patches of human mesangial cells in culture. Since BK(Ca) are important feedback regulators of contraction of smooth muscle and mesangial cells, these results indicate that MB may be an important opener of BK(Ca) channels and a regulator of vascular volume and resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-126 |
| Number of pages | 4 |
| Journal | Biochimica et Biophysica Acta - Biomembranes |
| Volume | 1285 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 4 1996 |
| Externally published | Yes |
Keywords
- Methylene blue
- Potassium ion
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology
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Cite this
Stockand, J. D., & Sansom, S. C. (1996). Activation by methylene blue of large Ca2+-activated K+ channels. Biochimica et Biophysica Acta - Biomembranes, 1285(2), 123-126. https://doi.org/10.1016/S0005-2736(96)00194-0