Activated rate processes and a specific biochemical mechanism for explaining delayed laser induced thermal damage to the retina

Bernard S. Gerstman, Randolph D. Glickman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Laser induced thermal damage to the retina is investigated. The one step Arrhenius type thermal damage integral of Henriques is analyzed for its strengths and weaknesses. The zero-order activated rate process is shown to well represent the data for pulse durations greater than 10 μs. A zero-order biochemical damage mechanism involving free radical formation and thermal disruption of the melanosome's protein coat is proposed as the initial molecular process that leads to cellular damage which appears after a delay. Data are presented that show the photoactivation of melanin granule oxidative reactivity. This in vitro data is evidence for an important step in our hypothesized damage pathway.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalJournal of Biomedical Optics
Volume4
Issue number3
DOIs
StatePublished - Jul 1 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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