Acquisition of cocaine self-administration with unsignaled delayed reinforcement in rhesus monkeys

Chad M. Galuska, James H. Woods

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Six experimentally naive rhesus monkeys produced 0.01 mg/kg/infusion cocaine by lever pressing under a tandem fixed-ratio 1 differential- reinforcement-of-other-behavior schedule. One lever press initiated an unsignaled 15- or 30-s delay culminating in cocaine delivery. Each press made during the delay reset the delay interval. With two exceptions, responding was acquired and maintained at higher rates than responding on a second (inoperative) lever. For the exceptions, a cancellation contingency was arranged in which each formerly inoperative-lever response reset the tandem schedule. This manipulation reduced presses on the inoperative lever. Subsequently, the consequences of responding on the two levers were reversed, and the monkeys again responded at higher rates on the operative lever. As a comparison, 3 additional experimentally naive monkeys received response-independent cocaine deliveries. Although lever pressing was observed, it extinguished and was subsequently reestablished under the tandem schedule. The results suggest that although response-reinforcer contiguity is not required for cocaine to acquire reinforcing functions, a response-reinforcer relation appears necessary.

Original languageEnglish (US)
Pages (from-to)269-280
Number of pages12
JournalJournal of the experimental analysis of behavior
Issue number2
StatePublished - Sep 2005
Externally publishedYes


  • Acquisition
  • Cocaine self-administration
  • Delayed reinforcement
  • Lever press
  • Rhesus monkey

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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