Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

Jie Lei; Zhi Gang Xu; Dian Yong Tang; Yong Li; Jia Xu; Hong Yu Li; Jin Zhu; Zhong Zhu Chen

doi:10.1021/acscombsci.8b00005

Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

Jie Lei, Zhi Gang Xu, Dian Yong Tang, Yong Li, Jia Xu, Hong Yu Li, Jin Zhu, Zhong Zhu Chen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

Original language	English (US)
Pages (from-to)	292-297
Number of pages	6
Journal	ACS Combinatorial Science
Volume	20
Issue number	5
DOIs	https://doi.org/10.1021/acscombsci.8b00005
State	Published - May 14 2018
Externally published	Yes

Keywords

6-methylpyrazin-2(1 H)-one
allene
multicomponent reaction (MCR)
substituted furans
Ugi reaction

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1021/acscombsci.8b00005

Cite this

@article{3bb761dd641b4c17896dbb8dbcec8638,

title = "Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ",

abstract = "Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.",

keywords = "6-methylpyrazin-2(1 H)-one, allene, multicomponent reaction (MCR), substituted furans, Ugi reaction",

author = "Jie Lei and Xu, {Zhi Gang} and Tang, {Dian Yong} and Yong Li and Jia Xu and Li, {Hong Yu} and Jin Zhu and Chen, {Zhong Zhu}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = may,

day = "14",

doi = "10.1021/acscombsci.8b00005",

language = "English (US)",

volume = "20",

pages = "292--297",

journal = "ACS Combinatorial Science",

issn = "2156-8952",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

AU - Lei, Jie

AU - Xu, Zhi Gang

AU - Tang, Dian Yong

AU - Li, Yong

AU - Xu, Jia

AU - Li, Hong Yu

AU - Zhu, Jin

AU - Chen, Zhong Zhu

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

AB - Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

KW - 6-methylpyrazin-2(1 H)-one

KW - allene

KW - multicomponent reaction (MCR)

KW - substituted furans

KW - Ugi reaction

UR - http://www.scopus.com/inward/record.url?scp=85046999840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046999840&partnerID=8YFLogxK

U2 - 10.1021/acscombsci.8b00005

DO - 10.1021/acscombsci.8b00005

M3 - Article

C2 - 29620860

AN - SCOPUS:85046999840

SN - 2156-8952

VL - 20

SP - 292

EP - 297

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

IS - 5

ER -

Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this