Acetylcholine and memory

Michael E. Hasselmo, James M. Bower

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

Acetylcholine may set the dynamics of cortical networks to those appropriate for learning of new information, while decreased cholinergic modulation may set the appropriate dynamics for recall. In slice preparations of the olfactory cortex, acetylcholine selectively suppresses intrinsic but not afferent fiber synaptic transmission, while decreasing the adaptation of pyramidal cells. In biologically realistic models of this region, the selective suppression of synaptic transmission prevents recall of previously learned memories from interfering with the learning of new memories, while the decrease in adaptation enhances the response to afferent input and the modification of synapses. This theoretical framework may serve to guide future studies linking neuromodulators to cortical memory function.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalTrends in Neurosciences
Volume16
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

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Acetylcholine
Synaptic Transmission
Learning
Pyramidal Cells
Synapses
Cholinergic Agents
Neurotransmitter Agents
Olfactory Cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Acetylcholine and memory. / Hasselmo, Michael E.; Bower, James M.

In: Trends in Neurosciences, Vol. 16, No. 6, 1993, p. 218-222.

Research output: Contribution to journalArticle

Hasselmo, ME & Bower, JM 1993, 'Acetylcholine and memory', Trends in Neurosciences, vol. 16, no. 6, pp. 218-222. https://doi.org/10.1016/0166-2236(93)90159-J
Hasselmo, Michael E. ; Bower, James M. / Acetylcholine and memory. In: Trends in Neurosciences. 1993 ; Vol. 16, No. 6. pp. 218-222.
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