Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis

J. B. Rotstein, T. J. Slaga

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Acetic acid, a very weak tumor promoter in the multistage mouse skin model for chemical carcinogenesis, was found to be very effective at enhancing cancer development, when applied during the progression phase of the model. Papilloma-bearing mice when repeatedly treated with acetic acid had a greater carcinoma incidence and a greater conversion of papillomas to carcinomas than vehicle treated mice. Selective cytotoxicity is discussed as a possible mechanism.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalCancer Letters
Volume42
Issue number1-2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • acetic acid
  • chemical carcinogenesis
  • mouse skin
  • tumor progression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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