Acetazolamide-eluting biodegradable tubular stent prevents pancreaticojejunal anastomotic leakage

Jung Hoon Park, Jieun Park, Yejong Park, Jeon Min Kang, Dae Sung Ryu, Jeongsu Kyung, Jong Keon Jang, Changmo Hwang, In Kyong Shim, Ho Young Song, Su Geun Yang, Song Cheol Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Postoperative pancreatic fistula at the early stage can lead to auto-digestion, which may delay the recovery of the pancreaticojejunal (PJ) anastomosis. The efficacy and safety of an acetazolamide-eluting biodegradable tubular stent (AZ-BTS) for the prevention of self-digestion and intra-abdominal inflammatory diseases caused by pancreatic juice leakage after PJ anastomosis in a porcine model were investigated. The AZ-BTS was successfully fabricated using a multiple dip-coating process. Then, the drug amount and release profile were analyzed. The therapeutic effects of AZ were examined in vitro using two kinds of pancreatic cancer cell lines, AsPC-1 and PANC-1. The efficacy of AZ-BTS was assessed in a porcine PJ leakage model, with animals were each assigned to a leakage group, a BTS group and an AZ-BTS group. The overall mortality rates in these three groups were 44.4%, 16.6%, and 0%, respectively. Mean α-amylase concentrations were significantly higher in the leakage and BTS groups than in the AZ-BTS group on day 2–5 (p < 0.05 each all). The luminal diameters and areas of the pancreatic duct were significantly larger in the leakage group than in the BTS and AZ-BTS groups (p < 0.05 each all). These findings indicate that AZ-BTS can significantly suppress intra-abdominal inflammatory diseases caused by pancreatic juice leakage and also prevent late stricture formation at the PJ anastomotic site in a porcine model.

Original languageEnglish (US)
Pages (from-to)650-659
Number of pages10
JournalJournal of Controlled Release
Volume335
DOIs
StatePublished - Jul 10 2021

Keywords

  • Inflammation
  • Pancreas
  • Pancreaticojejunal anastomosis
  • Postoperative pancreatic fistula
  • Stents

ASJC Scopus subject areas

  • Pharmaceutical Science

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