ACE2/angiotensin-(1–7)/mas receptor axis in the central nervous system

E. C. Brito-Toscano, N. P. Rocha, M. A. Rachid, A. L. Teixeira, A. S. de Miranda

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The renin–angiotensin system (RAS) is classically conceived as a circulating hormonal system involved in cardiovascular and renal homeostasis. The discovery that RAS components are locally expressed in the brain tissue pointed out to a role for this system in the pathophysiology of neuropsychiatric diseases, including mood disorders and neurodegenerative and cerebrovascular illnesses. The RAS counterregulatory axis composed by the angiotensin-converting enzyme 2 (ACE2), angiotensin-(1–7) (Ang-(1–7)), and Mas receptor mediates, among others, antiinflammatory, antioxidant, and antiapoptotic processes, frequently opposing the classical RAS arm (ACE/Ang II/AT1 receptor) actions. Accumulating evidence has supported protective roles of the ACE2/Ang-(1–7)/Mas receptor axis in the brain. Herein, we will discuss emerging evidence regarding the role of RAS, mainly focusing in the ACE2-Ang-(1–7)-Mas receptor arm, in brain physiology and pathophysiology. We will also report current experimental and clinical evidence in relation to ACE2 stimulation and Mas receptor agonists as potential therapeutic targets for neuropsychiatric diseases.

Original languageEnglish (US)
Title of host publicationAngiotensin
Subtitle of host publicationFrom the Kidney to Coronavirus
Number of pages21
ISBN (Electronic)9780323996181
ISBN (Print)9780323996198
StatePublished - Jan 1 2023
Externally publishedYes


  • Angiotensin-(1–7)
  • Angiotensin-converting enzyme
  • Brain
  • Cerebrovascular diseases
  • Mas receptor
  • Mood disorders
  • Neurodegenerative diseases
  • Renin–angiotensin system

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'ACE2/angiotensin-(1–7)/mas receptor axis in the central nervous system'. Together they form a unique fingerprint.

Cite this